Investigating the role of altered myoepithelial phenotype in the progression of DCIS of the breast.
|Funded by:||Pathological Society of Great Britain and Ireland||Stipend||£15,863 approximately per annum|
|Start date:||1 November 2014 provisionally||Duration:||
|Location||Centre for Tumour Biology|
|Deadline:||22 August 2014|
Who should apply:
The project works on one of the key themes of the research group, which is analysis of the role of the microenvironment in promoting the progression of pre-invasive breast disease to invasive cancer. The transition from DCIS to invasive cancer is critical, changing a potentially curable disease into one that is life-threatening. However, it is now evidence that only ~50% of DCIS will ever progress and there is a need to understand the mechanisms involved and how to identify those that will progress. We previously have shown that the integrin αvβ6 is up-regulated in a subset of DCIS and is associated with a more aggressive behaviour. The aim of this project is to investigate the hypothesis that up-regulation of the integrin αvβ6 is required for progression to invasive breast cancer, in a Fibronectin-dependent mechanism. The project will involve co-culture model systems, invasion and angiogenesis assays, and gene knock-down and over-expression, in addition to analysis of human tissues, thus providing broad cell biology experience.
Barts Cancer Institute is a vibrant research environment with a lively PhD community and an excellent training programme.
Informal enquiries should be made to Professor Louise Jones via e-mail: firstname.lastname@example.org
Support and Benefits
We implement a comprehensive support programme for our research students, providing training in a wide range of biomedical laboratory methods and other vital transferable skills. Our aim is to equip our students for a career in science and to make them attractive to a variety of potential employers.
We offer our students travel bursaries and grants to support students who are presenting at conferences and meetings.
The studentship is funded by the Pathological Society of Great Britain and Ireland and comes with a tax-free stipend of approximately £15,863 (MRC rates) per annum. It is open to UK Nationals, EEA/Swiss migrant workers and non-UK nationals with indefinite leave to remain in the UK who will have three years ordinary residence in the UK prior to the start of the studentship. University tuition fees (at the UK/EU level) will be met by the funding body.
To apply, please send a CV with a covering letter to Professor J L Jones.
- A minimum 2.1 undergraduate degree in biomedical sciences, or equivalent
- If English is not your first language IELTS score of 6.5 or equivalent
- The studentship is not open to non-EU nationals.
How to apply
You will need to provide:
- Completed PhD application form
- Statement of purpose
- Copy of transcripts (break down of marks)
- Copy of passport
- If applicable, proof of English proficiency
Deadline for applications is: 22 August 2014
Please ensure you provide all supporting documents, as we are unable to consider incomplete application forms. You must contact your referees directly to request references. They can send these seperately to email@example.com
We will be contacting all candidates who are shortlisted for an interview by email.
Interviews will take place on the 12th September 2014
|Tel:||+44(0) 207 882 3577|
|Tel:||+44(0) 207 882 2081|