Dr Adam Rosenthal
Research Interests
Dr Adam Rosenthal's main research themes are in: Gynaecological Cancer and Ovarian Cancer
My research interests include ovarian cancer screening, familial gynaecological cancer and the molecular biology of vulval neoplasia. My professional interests are the management of gynaecological cancers, especially using laparoscopic surgery, the assessment of risk in familial gynaecological cancer syndromes and screening for gynaecological cancers. I teach on various laparoscopic surgery courses.
I am Clinical Lead on the UK Familial Ovarian Cancer Screening Study, which is co-ordinated by the UCL Elizabeth Garret Anderson Institute for Women’s Health.
I am part of the vulval neoplasia research group, which includes members of the Barts Cancer Institute and the Centre for Cutaneous Research in the Blizard Institute of Cell and Molecular Sciences.
Profile
I qualified from St. Mary’s Hospital Medical School, London, in 1992. I then undertook general Obstetrics and Gynaecology training in London, working at various prestigious hospitals, including St. Mary’s, Queen Charlotte’s, the Hammersmith, and Chelsea and Westminster.
In 1999, I completed three years’ research at St. Bartholomew’s Hospital, leading to a PhD in the molecular biology of vulval cancer. During this period I also worked on the first randomised trial of ovarian cancer screening in the general population, and saw patients in the hospital's specialist Familial Cancer Clinic and Vulval Clinic.
In 2008, I completed three years' subspecialty training in gynaecological oncology and minimal access surgery at University College Hospital (UCH), London. Whilst there, I helped to set up Phase Two of the UK Familial Ovarian Cancer Screening Study (UK FOCSS). This is the world's largest trial of ovarian cancer screening in women at increased risk of the disease.
Since January 2010, I have been Consultant Gynaecological Oncologist and Senior Lecturer at St. Bartholomew’s Hospital, London. I am also an Honorary Consultant Gynaecological Oncologist at UCH, London, and Honorary Senior Lecturer at University College London, from where I am Clinical Lead on the UK FOCSS.
I have published extensively on ovarian cancer screening and the molecular biology of gynaecological cancer in journals including the Lancet, the Journal of Clinical Oncology and the British Journal of Cancer. I hold a number of grants from Cancer Research UK, NHS Research and Development, the Eve Appeal and the BUPA Foundation.
My main clinical interests are laparoscopic and open gynaecological cancer surgery, colposcopy, gynaecological cancer screening, vulval diseases and inherited (familial) gynaecological cancers.
Funding
Grants (Total £8 Million)
- Risk stratification, early detection and diagnosis of cancer 2011-2016 - Co-investigator: CR UK (£1.6m), The Eve Appeal (£1.6m), UCL CBRC (£800k)
- UK FOCSS 2005-11, CR UK PBSC £864k - Co-investigator
- UK FOCSS 2005-11, The Eve Appeal £700k - Co-investigator
- UK FOCSS serum bank 2007-11, CR UK TRICC £370k - Co-investigator
- UK FOCSS Excess Treatment Costs 2007-11, NHS R+D £1.8m - Co-investigator
- PsyFOCS 2007-12, BUPA Foundation, £300k – Co-investigator
Key Publications
SJ Klug, M Ressing, J Koenig, MC Abba, T Agorastos, SMF Brenna, M Ciotti, BR Das, A Del-Mistro, A Dybikowska, AR Giuliano, Z Gudleviciene, U Gyllensten, ALF Haws, A Helland, SC Herrington, A Hildesheim, O Humbey, SH Jee, JW Kim, MM Madeleine, J Menczer, HYS Ngan, A Nishikawa, Y Niwa, R Pegoraro, MR Pillai, G Ranzani, G Rezza, AN Rosenthal, S Roychoudhury, D Saranath, VM Schmitt, S Sengupta, W Settheetham-Ishida, H Shirasawa, PJF Snijders, MH Stoler , AE Suárez-Rincón, K Szarka, R Tachezy, M Ueda, AGJ van der Zee, M von Knebel Doeberitz , M-T Wu, T Yamashita, I Zehbe, M Blettner. TP53 codon 72 polymorphism and cervical cancer: pooled analysis of individual data of 15 834 women from 49 studies. Lancet Oncol 2009; 10:772-84. 19625214
R Manchanda, A Rosenthal, M Burnell, L Fraser, J Mackay, S Skates. Change in stage distribution observed with annual screening for ovarian cancer in BRCA carriers. J Med Genet 2009;46:423-4. 19487541
A Rosenthal, U Menon, I Jacobs. Ovarian cancer screening. In Reznek R. Cancer of the ovary. Contemporary issues in cancer imaging - a multidisciplinary approach. Cambridge University Press, Cambridge 2007.
AN Rosenthal, U Menon, IJ Jacobs. Screening for ovarian cancer. Clinical Obstetrics and Gynecology 2006;49: 433-47. 16885651
A Rosenthal, I Jacobs. Familial ovarian cancer screening. Best Practice and Research Clinical Obstetrics and Gynaecology 2006;20: 321-38. 16364691
AN Rosenthal, IJ Jacobs. Overview of ovarian cancer screening. In J. Bonnar, W. Dunlop. Recent Advances in Obstetrics and Gynaecology Volume 23. RSM Press, London 2005.
U Menon, SJ Skates, S Lewis, AN Rosenthal, B Rufford, K Sibley, N MacDonald, A Dawnay, A Jeyarajah, RC Bast Jr, D Oram, IJ Jacobs. A prospective study using the Risk of Ovarian Cancer Algorithm to Screen for Ovarian Cancer. J Clin Oncol 2005;23:7919-26.
Research Group
UK Familial Ovarian Cancer Screening Study
Vulval neoplasia research group
