Prof. Balkwill's lab in new collaborative agreement to help prove the potential of a new drug programme to treat cancer. Read more.
Professor Fran Balkwill
My research is focused on the links between cancer and inflammation, being especially interested in translating knowledge of cancer biology into new biological treatments for cancer and in the role that inflammatory cytokines play in cancer promotion.
My key areas of interest are:
- The Tumour Microenvironment
- Inflammatory cytokines and chemokines in the tumour microenvironment
- 'Ovarian' cancer with a focus on high grade serous and clear cell subtypes
- Public engagement with biomedical science and science policy
I am Professor of Cancer Biology at Barts Cancer Institute, Queen Mary University of London, where I lead the Centre for Cancer and Inflammation and the Cytokine and Cancer group within that Centre. I study the links between cancer and inflammation and research ways of translating this to clinical trial.
In 2006, I was made a Fellow of the Academy of Medical Sciences, being elected a member of its Council later in the same year. I am a frequent plenary and keynote speaker at international meetings, such as Gordon and Keystone conferences and the American Association for Cancer Research (AACR).
I am also actively involved in communication of science to non-specialist audiences, especially young people. I have written thirteen science books for children on cell and molecular biology, with titles such as Enjoy Your Cells and The Egg and Sperm Race.
I am the Director of the Centre of the Cell, a £4 million biomedical science centre for children, educational website and outreach in Whitechapel. The website was launched in March 2007 and the physical Centre opened in September 2009. As of January 2012 there have been over 42,000 participants in Centre of the Cell activities.
I am a non-parliamentary board member of the Parliamentary Office of Science and Technology, POST, Chair of Understanding Animal Research (UAR) and a member of the Royal Society Faraday Award Committee. I am on the Scientific Advisory Committee of Breakthrough Breast Cancer I was awarded an OBE in the 2008 Queen's Birthday Honours list.
- Affitech Collaboration Grant 2011
Validation of CCR4 Antibody
- BBSRC Industrial CASE Studentship with AstraZeneca 2009-2013
Role of Chemokine CXCL12 in Cell-Cell and Cell-Matrix Interactions in Normal and Pathological Processes
- Cancer Research UK Programme Grant 2008-2013
Targeting Cancer-Related Inflammation
- Archibald KM, Kulbe H, Kwong J, Chakravarty P, Temple J, Chaplin T, Flak MB, McNeish IA, Deen S, Brenton JD, Young BD, Balkwill FR. Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium. Oncogene in press 2012.
- Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill FR. A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. Cancer Res. 2011 Nov 7. 2011; DOI:10.1158/0008-5472.CAN-11-2178
- Maniati E, Bossard M, Cook N, Candido JB, Emami-Shahri N, Nedospasov SA, Balkwill FR, Tuveson DA, H
Zagemann T. Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. J Clin Invest. 2011 Nov 7. pii: 45797. doi: 10.1172/JCI45797. 4685–4699
- Schioppa T, Moore R, Thompson R, Rosser E, Kulbe H, Nedospasov S, Mauri C, Coussens LM, Balkwill FR. B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis. PNAS U S A. 2011 Jun 28;108 (26):10662-7.
- Charles KA, Kulbe H, Soper R, Escorcio-Correia M, Lawrence T, Schultheis A, Chakravarty S, Thompson RG, Kollias G, Smyth JF, Balkwill FR*, Hagemann T*. The Importance of T cells and IL-17 in the Tumor-Promoting Actions of TNF-a. J Clin Invest 2009: 119(10), 3011-23 *equal contribution
For additional publications, please click here.
|Lab Manager||Monica Canosa|
|Centre Administrator||Emily McLean-Inglis|
|Ganga Gopinathan||PhD Student|
|Laura King||PhD Student|
|Zohra Gueroui||Medical Laboratory Assistant|
|Dr Chiara Berlato||Postdoctoral Research Assistant|
|Dr Hagen Kulbe||Postdoctoral Research Assistant|
|Dr Carla Milagre||Postdoctoral Research Assistant|
|Dr Anne Montfort||Postdoctoral Research Assistant|
|Richard Thompson||Research Technician|
|Jenny Cook||PhD Student|
|Juliana Candido||hPD Student|
|Nia Emami-Shahri||PhD Student|
|Dr Fiona McCarthy||Clinical research Fellow|
|Dr Cristina Ghirelli||Postdoctoral Research Assistant|
|Dr Eleni Maniati||Postdoctoral Research Assistant|
|Dr Raphael Zöllinger||Postdoctoral Research Assistant|
|Dr Thorsten Hagemann||Clinical Senior Lecturer|
B cell Differentiation
|Dr Melania Capasso||Lecturer|
- Centre of the Cell
- Barts and The London Charity
Cancer Research Committee
- Barts and The London School of Medicine and Dentistry
Charterhouse Square Working Group (Chair)
- Parliamentary Office of Science and Technology (POST)
Non-Parliamentary Board Member
- Royal Society
Michael Faraday Medal Award Committee
- Understanding Animal Research
Committee Member (Chair)
- Breakthrough Breast Cancer
Scientific Advisory Commitee Member
- February 2011: Awarded the 19th Otto Herz Memorial Cancer Research Lectureship at Tel Aviv University, Israel
- May 2011: Keynote lecturer at the 13th International Meeting on TNF in Japan
- Professor Fran Balkwill's lab in new collaborative agreement to help prove the potential of a new drug programme to treat cancer, click here to read more.