Dr Pedro R. Cutillas
Dr Pedro Cutillas's main research themes are in: Bioinformatics, Cancer Cell Biology, Cell Signalling, Drug Resistance, Haematological Malignancies, Leukaemia, Lymphoma, Metabolism and Mass Spectrometry
I am interested in understanding how cell signalling pathways driven by the activity of protein kinases contribute to the development of cancer. Signalling pathways do not work in isolation but form a complex network of biochemical reactions that integrate extracellular signals into a coordinated cell biological response.
Essentially all cancers deregulate one or several components of this biochemical network, but unfortunately, cancers are heterogeneous in the way signalling is perturbed. In practice, this means that novel targeted therapies against signalling nodes do not work equally well in all patients. Even those patients that initially respond eventually develop resistance.
To understand the mechanisms underlying this heterogeneity, I developed methodology based on a technique named mass spectrometry and on computational science. These techniques can be used to measure how the signalling network is wired in individual cancer populations in a comprehensive and unbiased manner.
My group is now using these unique resources to investigate the fundamental properties of signalling networks and to understand how signalling heterogeneity in cancer (with particular focus on haematological malignancies) contribute to intrinsic and acquired resistance to compounds that target signalling enzymes.
I graduated with a PhD in 2004 from UCL. My studies (completed in the laboratories of Prof Mike Waterfield, Prof Rainer Cramer and Prof Al Burlingame) were on a project that investigated kidney physiology and were supervised by Prof Robert Unwin. I then completed postdoctoral training at the Ludwig Institute for Cancer Research (UCL branch).
In 2007, I became lecturer at the Centre for Cell Signalling and in 2010 I was promoted to Senior Lecturer. After a period in the MRC Clinical Sciences Centre (2012-2013), where I was Head of the Mass Spectrometry and Proteomics, I joined the Centre for Haemoto-Oncology in 2013 where I now lead the Integrative Cell Signalling and Proteomics Group.
Only grants awarded as Principal Investigator are listed:
- Barts and The London Charity 2009 – 2014; Value £492,000
- European commission Jan2011-Dec 13; Value: £110,000
- BBSRC 2009 - 2012; Value £392,000
- CRUK 2008 - 2011; Value: £180,000
- The Heptagon Proof of Concept Fund 2008; Value £74,000
- Barts and the London Charity 2007 - 2009; Value: £108,000
Casado P, Alcolea MP, Iorio F, Rodriguez-Prados JC, Saez-Rodriguez J, Vanhaesebroeck B, Joel S, Cutillas PR. Phosphoproteomics data classify haematological cancer cell lines according to tumour type and sensitivity to kinase inhibitors. Genome Biology 2013; 13:R37 PMID: 23628362
Casado, P, Rodríguez-Prados JC, Cosulich SC, Guichard, S, Vanhaesebroeck B, Joel S, Cutillas PR. Kinase-Substrate Enrichment Analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells. Science Signaling 2013; 3: rs6 PMID: 23532336
[This article was selected for the special issue that Science Magazine dedicated to Cancer Genomics]
Alcolea MP, Casado P, Rodríguez-Prados JC, Vanhaesebroeck B, Cutillas PR. Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance. Mol Cell Proteomics. 2012 Aug;11(8):453-66. PMCID: PMC3412974.
Beltran L, Chaussade C, Vanhaesebroeck B, Cutillas PR. Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity. Proc Natl Acad Sci U S A. 2011;108(39):16217-22. PMCID: PMC3182684.
For additional publications, please click here.
Integrative Cell Signalling and Proteomics
- Dr Pedro Casado
- Dr Vinothini Rajeeve
- Dr Essam Ghazaly
- Mr Edmund Wilkes
- Founding Director, Activiomics Ltd
- Member of the Steering Committee of The London Biological Mass Spectrometry Discussion Group (LBMSDG)