BCI on the Road
Dr Jude Fitzgibbon speaking to lymphoma support group at Basildon University Hospital
Dr Jude Fitzgibbon in the Centre for Haemato-Oncology is speaking to the lymphoma support group at Baslidon University Hospital on Monday 18 July, about his research funded by the Leukemia and Lymphoma Research Charity.
Follicular lymphoma (FL) is an incurable cancer of the B-cells, representing 25% of all Non-Hodgkin's Lymphomas.
It nearly always affects adults, and the average age at diagnosis is 60.
It is characterised by upregulation of a survival protein called BCL2 and the accumulation of a long lived pool of B cells, in which additional mutational changes can occur.
We now know that many of these changes target the cells epigenetic machinery, altering the transcriptional control of many hundred of genes and switching B cells from a Œnormal¹ to a Œcancerous¹ path.
With funding from the Leukaemia Lymphoma Research Charity we are trying to understand how this switch is likely to occur and if by reversing its effects we can identify novel methods of treating this lymphoma. -Dr Jude Fitzgibbon
Related links:
Most influential discoveries in cancer - Prof Ian Hart invited to speak at Milestones in Cancer seminar series, Cologne
Professor Ian Hart will be speaking at the Cologne Cancer Club at the University of Cologne as part of their Milestones in Cancer series.
This seminar series hosts speakers that have been featured in Nature Milestones Cancer, which highlight the most influential discoveries in the field of cancer over the past century.
Professor Hart will be speaking on “The role of integrin αvβ6 in determining carcinoma cell invasion and metastasis.” Milestone 1 Seed and soil hypothesis.
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- BCI researchers working on metastasis and invasion.
The 16th European Haematology Association Congress, see who’s presenting from the BCI
The EHA congresses present the latest scientific and clinical research in all aspects of hematology, as well as ‘state of the art’ Education Sessions for clinicians and hematologists in training. This year the 16th EHA Congress will take place in London, UK on the 9-12th June 2011.
A group of BCI researchers from our Centre for Haemato-Oncology will be presenting their work at the congress, if you are attending please drop by and see them present their work.
Sessions:
- Friday, 10 June 2011 17:45-19:00 0028
Acute myeloid leukemia - Biology 1
High-throughput clonal sequencing of small rna transcriptome in acute myeloid leukaemia characterised hundred of novel small rna molecules
S Debernardi, J Wang, J Marzec, F Manodoro, C Mein, A Curtotti, B Young
- Friday, 10 June 2011 17:45-19:00 0033
Acute myeloid leukemia - Biology 1
Global dna methylation analysis of acute myeloid leukaemia reveals leukaemia-specific and subtype-specific patterns associated with gene promoters, cpg islands and repeat elements
Dr Saied, S K Khaled, T D Down, J M Marzec, S D Derbernardi, M R Raghavan, B Y Young
- Friday, 10 June 2011 17:45-19:00 0344
Non-Hodgkin lymphoma - Biology
Deep sequencing reveals a complex pattern of clonality in follicular lymphoma by analysis of the heavy chain of the immunoglobulin gene in different tumor sub-populations
CE Carlotti, G Rosignoli, A Sangaralingam,T Chaplin, S Iqbal, J Matthews, M Calaminici, BD Young, TA Lister, P Campbell, JG Gribben
- Saturday, 11 June 2011 08:15-08:30 0475 Hall S4
Non-Hodgkin Lymphoma - From biology to therapy
Depletion of tumour associated macrophages significantly retards the progression of an aggressive and chemoresistant model of b-cell non hodgkin lymphoma
S Hallam, J Candido, E Dr Maniati, R Thompson, N Dr Van Rooijen, T Dr Hagemann, J Professor Gribben
- Saturday, 11 June 2011 17:30-18:45 0586
Acute myeloid leukemia - Biology 2
Acute myeloid leukemia induces bone marrow failure by inducing dormancy in normal hematopoietic stem cells
F Miraki-Moud, E Griessinger, J G Gribben, D Bonnet, D C Taussig
- Saturday, 11 June 2011 17:30-18:45 0589
Acute myeloid leukemia - Biology 2
High-throughput bisulfite amplicon sequencing of the 14q32 imprinted domain identifies dna methylation signatures in acute myeloid leukaemia
F Manodoro, J Marzec ,T Chaplin , J Wang, B Young ,S Debernardi
View all our senior researchers working on Haematological Malignancies.
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