BCI at the American Association for Cancer Research Annual Meeting 2012, Chicago IL

BCI researchers will be presenting a variety of presentations and posters at the American Association for Cancer Research Annual Meeting, McCormick Place West, Chicago.

Sunday 01 April 2012

Session Title - Cell-Cell Interactions
Session Type - Poster Session
Session Time - 1:00 - 5:00 PM
49/20 - Targeting the TNF network in human ovarian cancer - A systems biology approach
Hagen Kulbe¹, Probir Chakravarty², Robert Moore², Francesco Iorio³, Alexander Montoya¹, Julio Saez-Rodriguez³, Pedro Cutillas¹, Frances Balkwill¹. ¹Barts Cancer Inst., London, United Kingdom; ²Cancer Research UK, London, United Kingdom; ³EMBL European Bioinformatics Institute & Wellcome Trust Sanger Institute, Cambridge, United Kingdom⁰

Session Title - Cell Receptor Oncogenes
Session Type - Poster Session
Session Time - 1:00 - 5:00 PM
6/6 - Investigating the functional significance of FGFR2 SNP status in breast cancer
Luisa Robbez-Masson, Richard Grose. Barts Cancer Institute, London, United Kingdom⁰

Session Title - Molecular Diagnostics for Personalized Cancer Therapy
Session Type - Minisymposium
Session Time - 3:15 - 5:15 PM
964 - Intra-tumor heterogeneity and Darwinian selection revealed by multi-region exome sequencing of renal cell carcinomas (3:50 PM)
Marco Gerlinger¹, Andrew Rowan², Stuart Horswell², James Larkin³, David Endesfelder², Eva Gronroos², Pierre Martinez², Nicholas Matthews², Aengus Stewart², Patrick Tarpey⁴, Ignacio Varela⁴, Benjamin Phillimore², Sharmin Begum², Neil McDonald², Adam Butler⁴, David Jones⁴, Keiran Raine⁴, Calli Latimer⁴, Claudio Santos², Mahrokh Nohadani⁵, Aron Eklund⁶, Bradley Spencer-Dene², Graham Clark², Lisa Pickering³, Gordon Stamp², Martin Gore³, Zoltan Szallasi⁷, Julian Downward², P. Andrew Futreal⁴, Charles Swanton⁸. ¹Cancer Research UK London Research Institute and Barts Cancer Institute, London, United Kingdom; ²Cancer Research UK London Research Institute, London, United Kingdom; ³Royal Marsden Hospital, London, United Kingdom; ⁴WellcomeTrust Sanger Institute, Hinxton, United Kingdom; ⁵Institute of Cancer Research, London, United Kingdom; ⁶Denmark Technical University, Lyngby, Denmark; ⁷Harvard Medical School, Boston, MA; ⁸Cancer Research UK London Research Institute and UCL Cancer Institute, London, United Kingdom⁰

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Monday 02 April 2012

Session Title - Kinase and Phosphatase Inhibitors 2
Session Type - Poster Session
Session Time - 8:00 AM - 12:00 PM
1792/8 - The potential role of targeting HER1-4 in bladder cancer
Christiana Kitromilidou¹, Douglas McDonald², Pedro Cutillas¹, Essam Ghazaly¹, Jackie Perry¹, Bodor Csaba¹, Simon Joel¹, Tom Powles¹. ¹Queen Mary University of London, London, United Kingdom; ²University College London, London, United Kingdom

Session Title - Disruptors of Protein Interaction and Homeostasis
Session Type - Poster Session
Session Time - 1:00 - 5:00 PM
2793/28 - Targeting the unfolded protein response as a therapeutic approach in hematological malignancies
Linsey Madadi, Simon Joel. Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of⁰ London, London, United Kingdom⁰

Session Title - Biological Therapy Based on Viruses, Antibodies, or Metformin
Session Type - Poster Session
Session Time - 1:00 - 5:00 PM
2712/1 - A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells
Katrina G. Sweeney, Siew C. Cheong, Nick R. Lemoine, Gunnel Halldén. Barts Cancer Institute, London, United Kingdom⁰

2713/2 - Adenovirus E1A binding to p300 is essential for synergistic cell killing in combination with chemotherapeutic drugs in prostate cancer cells
Hector R. Maya-Pineda, Enrique Miranda-Rota, Nick R. Lemoine, Gunnel Halldén. Barts Cancer Institute, London, United Kingdom⁰

Session Title - Late-Breaking Research: Immunology
Session Type - Late-Breaking Poster Session
Session Time - 1:00 - 5:00 PM
LB-129 - CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model
Yajun Yang¹, Xiaozhu Li¹, Yaohe Wang², Shengdian Wang¹. ¹Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; ²Center for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom⁰

Session Title - Joint Cancer Immunology (CIMM)/Tumor Microenvironment (TME) Working Group Evening Scientific Session
Session Type - Special Session
Session Time - 6:00 - 8:00 PM
Tumor-promoting cytokine networks (6.45 PM)
Frances R. Balkwill. Barts Cancer Institute, London, United Kingdom⁰

Tuesday 03 April 2012

Session Title - Functional Identification and Characterization of New Cancer Genes
Session Type - Minisymposium
Session Time - 3:00 - 5:00 PM
4858 - Identification of ZDHHC14 as a novel tumor suppressor gene commonly downregulated in human cancers (4:20 PM)
Marc Yeste-Velasco¹, X. Mao¹, R. Grose², S.C. Kudahetti¹, D. Lin¹, T. Chaplin³, L. Xue¹, M. Xu¹, J.M. Foster¹, S. James¹, A.M. Chioni², S. Jeetle¹, N.A. Vasiljević⁴, J. Marzec³, D. Gould⁵, L. Jones², A.T. Lorincz⁴, R. T. D. Oliver¹, S.J. Mather¹, J.M. Shipley⁶, D.M. Berney¹, B.D. Young³, Y-J. Lu¹. ¹Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom; ²Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom; ³Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom; ⁴Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United⁰ Kingdom; ⁵Bone and Joint Research Unit, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom; ⁶Molecular Cytogenetics Laboratory, Institute of Cancer Research, Sutton, United Kingdom, London, United Kingdom⁰

Session Title - Tumor Progression
Session Type - Poster Session
Session Time - 8:00 AM - 12:00 PM
3256/19 - Sphingolipid regulation by sphingosine kinase anchoring protein (SKAP) and its implication in cancer
Essam A. Ghazaly, Paul Smith, Adedayo Oke, Jackie Perry, Zeinab Al-Shareef, Bryan D. Young, Simon Joel. Barts Cancer⁰ Institute, Queen Mary University of London, London, United Kingdom⁰

Session Title - Targeting Cancer Metabolism
Session Type - Poster Session
Session Time - 8:00 AM - 12:00 PM
3209/2 - Metformin suppresses the growth and modulates the metabolic profiles of pancreatic cancer cells under hypoxia in an IKKβ-dependent manner
Nia Emami-Shahri, Eleni Maniati, Maud Bossard, Thorsten Hagemann. Barts Cancer Institute, London, United Kingdom⁰

Session Title - Immunomodulation and Combinatorial Immunotherapy
Session Type - Poster Session
Session Time - 1:00 - 5:00 PM
4391/8 - CD20 as a target for therapy in solid tumors
Nesrine I. Affara¹, Brian Ruffell¹, Magnus Johansson¹, Kerri Fujikawa¹, Emily Bergsland¹, David G. DeNardo¹, Heather I. Chen¹, Nikhil Wadhwani¹, Martin Steinhoff¹, Morgan Truitt¹, Peter Olson¹, Douglas Hanahan¹, Yijin Li², Qian Gong², Yan Ma², Jane F. Wiesen¹, Grace Kim¹, Margaret Tempero¹, Frances Balkwill³, Bryan Irving², Lisa M. Coussens¹. ¹UCSF, San Francisco, CA; ²Genentech Inc., South San Francisco, CA; ³Queen Mary University of London, London, United Kingdom