Articles tagged with: Cover images

Vitamin A could boost pancreatic cancer chemotherapy

Posted in In the Press, Publications Published by Zoe Leech 25 May 2016

Vitamin A could boost pancreatic cancer chemotherapy

The latest study from the Kocher lab, published recently in the Journal of Pathology, has found that adding high doses of a form of vitamin A could help make chemotherapy more successful in treating pancreatic cancer.

This finding is now being taken forward in the clinical trial, STARPAC, by our Centre for Experimental Cancer Medicine.

FDA approves new bladder cancer treatment following BCI-led clinical trial

Posted in General News Published by Zoe Leech 20 May 2016

Tecentriq is the first PD-L1 inhibitor approved by the FDA

FDA approves new bladder cancer treatment following BCI-led clinical trial

Following a groundbreaking trial of a new bladder cancer treatment published in Nature in late 2014 and led by the BCI, the US Food and Drug Administration has now approved the immunotherapy for patients with advanced disease.

This is the first treatment advance for this cancer type in 3 decades and, now it has received first approval, should help many patients for whom existing treatments have not proved effective. European approval will hopefully follow.

New method to predict which pancreatic cancers are more aggressive

Posted in Publications Published by Zoe Leech 17 February 2015

New method to predict which pancreatic cancers are more aggressive

Dr Claude Chelala and her Bioinformatics group have tested a new way to classify and recommend treatment for pancreatic cancer patients. The results were published recently in Genome Medicine.

With further work to understand pancreatic cancer biology, the 36-gene signature they have described should provide opportunities to develop new drugs and methods to identify high-risk patients...

Nature: BCI-led trial of breakthrough therapy for advanced bladder cancer

Posted in In the Press, Publications Published by Zoe Leech 26 November 2014

Nature: BCI-led trial of breakthrough therapy for advanced bladder cancer

Professor Tom Powles and his clinical colleagues have made a breakthrough in developing a new therapy for advanced bladder cancer, for which there have been no major treatment advances in the past 30 years.

Published today in Nature, the findings present an antibody called MPDL3280A, which binds to the PD-L1 protein, as a promising therapy for metastatic urothelial bladder cancer (UBC)...

Nature Materials Cover: matrix density and breast cells

Posted in Images, Publications Published by Zoe Leech 22 May 2014

Nature Materials Cover: matrix density and breast cells

A paper published recently by the Roca-Cusachs group in Barcelona, with contributions from BCI's Drs Michael Allen, Jenny Gomm, John Marshall and Professor Louise Jones, is featured on the cover of Nature Materials.

It is also featured in the current issue's News and Views section...

CLL cells nurse themselves healthier by manipulating the microenvironment

Posted in Images, Publications Published by Marianne Baker 13 March 2014

CLL cells nurse themselves healthier by manipulating the microenvironment

A new paper has been published by Dr Li Jia and her colleagues in the Centre for Haemato-Oncology. The research brings us closer to understanding how chronic lymphocytic leukemia (CLL) changes its local environment in the body to support and encourage its own growth; which was not known before now.

In CLL, the production of a type of white blood cells called lymphocytes becomes faulty, leading to an accumulation of abnormal lymphocyte-like cancer cells...

Image from Dr Ezra Aksoy's latest BCI publication makes the cover of Nature Immunology journal

Posted in Images, Publications Published by Katherine Yuk 09 November 2012

Image from Dr Ezra Aksoy's latest BCI publication makes the cover of Nature Immunology journal

Limiting immune reactions is critical for protecting the host from harm. The work by Dr Ezra Aksoy led by Professor Bart Vanhaesebroeck has revealed how p110delta (δ) isoform of the PI3K fine-tunes inflammation to avoid excessive reactions that can damage the organism...

Image from Dr Alan Ramsay's latest BCI publication makes the cover of Blood journal

Posted in Images, Publications Published by Kaye Yeung 21 August 2012

Image from Dr Alan Ramsay's latest BCI publication makes the cover of Blood journal

The study included confocal imaging to investigate how cytotoxic T lymphocytes from chronic lymphocytic leukemia patients form actin-polarised immunological synapses with autologous tumor cells after down-regulation of tumor cell-inhibitory molecule expression using neutralising antibodies and the immunomodulatory drug lenalidomide...

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