The Barts Pancreatic Tissue Bank is part of the Barts and The London Hospital Human Tissue Resource Centre. The purpose of the tissue bank is to collect, store and share high quality tissue for translational research into pancreatic cancer.
The Pancreatic Cancer Research Fund aims to fund the National Pancreas Tissue Bank to enable sample and data collection nationally from pancreatic cancer patients with appropriate controls. The initial key centres include Barts Cancer Institute, University Council London, Southampton, Oxford, Leicester, Swansea and Glasgow. All of these centres will be coordinated by the BCI.
Over 1000 patients per year will be recruited together with 1000 controls. Each patient will generate multiple samples (frozen tissue, pancreatic and biliary juices, paraffin blocks, cells, blood, urine) collected using a secure, web-based, clinical annotation platform. This bio-repository will generate processed DNA and RNA for analysis, as well as cell lines and derived models, in keeping with the 3Rs principle.
The aim is to expand this tissue bank to another 24 centres when the initial set-up and SOPs and SLAs are complete. All tissue based molecular, genomic, proteomic (and other –omics) data will be available in an open source, bioinformatic environment to facilitate early translation of discovered biomarkers and treatment strategies into clinical use by reducing duplication and providing a large case-controlled sample base.
|The Pancreatic Tissue Bank Team||Role|
|Mr Hemant Kocher||Principal investigator|
|Professor Thorsten Hagemann||Principal investigator|
|Dr Mohammed Ikram||Tissue bank technician|