Professor Ian Hart
My main research interests are in how malignant cancers are able to invade, spread and metastasise and my research programme aims to understand better:
- How tumour cells progress and spread throughout the body.
- How stromal cell modification of metastatic spread can occur.
- How cytoadhesion, both cell-to-cell and cell-to-substrate, impacts upon cancer cell invasion and tumour dissemination.
I am Professor of Tumour Biology and Deputy Director of Barts Cancer Institute, Queen Mary, University of London. Qualifying as a Veterinary Surgeon in 1972, I worked in mixed practice for 1 year before gaining a PhD in Veterinary Pathology in 1976. I then worked in the USA, at Frederick Cancer Centre, until 1983, returned to head a laboratory at the ICRF from 1983 – 1993, joined King's College London as "Richard Dimbleby Professor of Cancer Research" from 1993 – 2003 and then moved to Barts and The London School of Medicine, where I am now running down gently to retirement in 2011.
Among stints on several grants panels and committees, I became Chairman of Cancer Research UK's Biological Sciences Funding Committee in April 2008. My research interests lie in how malignant cancers are able to metastasise.
- Cancer Research UKTraining Programme in Molecular Pathology 2005-2010 £5,000,000
- Cancer Research UK Programme Grant 2005-2010 £565,247
- St Bartholomew’s & The Royal London Charitable Foundation Training Fellowship 2005-2007 £93,303
- Royal College of Pathologists Health Foundation Fellowship 2004-2007 £533,044
- Cancer Research UK Competitive Staff Pool 2004 £390,920
- MercK KgaA Research Contract 2004-2005 £17,873 "Cilengitide on Primary Tumour Growth"
- MRC Co-operative Group Grant 2005 £535,171
Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome. Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EM, Tybulewicz VL, Hart IR, Hodivala-Dilke KM. Nature. 2010 Jun 10;465(7299):813-7.PMID: 20535211
alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice. Reynolds LE, Conti FJ, Silva R, Robinson SD, Iyer V, Rudling R, Cross B, Nye E, Hart IR, Dipersio CM, Hodivala-Dilke KM. J Clin Invest. 2008 Mar;118(3):965-74. PMID: 18246199
Ezrin interacts with cortactin to form podosomal rosettes in pancreatic cancer cells. Kocher HM, Sandle J, Mirza TA, Li NF, Hart IR. Gut. 2009 Feb;58(2):271-84. PMID: 18852256
High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin alphavbeta6. Saha A, Ellison D, Thomas GJ, Vallath S, Mather SJ, Hart IR, Marshall JF. J Pathol. 2010 Sep;222(1):52-63. PMID: 20629113
For additional publications, please click here.
- Chairman – Biological Sciences Committee, Cancer Research UK
- Member – Veterinary Fellowships Panel, Wellcome Trust
- Member – College of Experts, Medical Research Council