Professor Nick Lemoine
Centre Lead, Centre for Experimental Cancer Medicine
Research Interests
Professor Nick Lemoine's main research themes are in: Cancer Genomics, Clinical Trials, Gene Therapy, Pancreatic Cancer, Virotherapy and Oncolytic Viruses
I work with Dr Claude Chelala and Dr Tatjana Crnogorac-Jurcevic on the genomics and molecular pathology of pancreatic cancer. We use global profiling approaches at the genomic and proteomic levels to identify targets that can be exploited for detection and treatment of this disease. We are also developing novel platforms and algorithms for the bioinformatic interrogation and interpretation of very large, multidimensional datasets.
I work with Dr Yaohe Wang and Dr Gunnel Hallden on the development of oncolytic virotherapy, an approach that uses adenoviruses and vaccinia viruses that selectively replicate within and kill cancer cells, but leave normal cells untouched. We are also working on defining the cell survival signalling circuits that determine the sensitivity of cancer cells to this approach. The role of the immune system in modulating viral replication and tumour cell destruction is the focus of a major new programme.
As Lead for the Centre for Experimental Cancer Medicine, I am responsible for the management of a 40-strong team who support over 120 clinical trials currently open at Barts. They are involved at all stages of the trial process from its design, to obtaining ethics approval and NHS permission, in setting up the study and its initiation, to recruitment of patients into the studies, and the analysis and follow up. In addition, the Centre also ensures quality assurance and monitoring of the studies and compliance with the EU legislative governance requirements for running clinical trials.
Profile
I was Professor of Molecular Pathology at Imperial College London, where I was Director of the Cancer Research UK Molecular Oncology Unit and the first Director of the National Translational Cancer Research Centre at Hammersmith Hospital. Before that, I held academic positions at the Royal Postgraduate Medical School, London and The University of Wales College of Medicine in Cardiff. I trained in medicine at St Bartholomew's Hospital Medical College where I qualified with the University of London Gold Medal in 1983, specialising in pathology and oncology with posts in London and Cardiff.
I recently stepped down as Chairman of the MRC Clinical Research & Career Development Panel and the National Institute of Health Research Clinician Scientist Appointments & Review Panel. I previously chaired the MRC Stem Cell Fellowship Panel, the CR-UK Clinician Scientist and Senior Clinician Fellowship Panel and the MRC Experimental Medicine Review Panel for the Molecular & Cellular Medicine Board. I have been a long-serving member of the Gene Therapy Advisory Committee at the Department of Health, as well as CR-UK Science Funding Committee, MRC Molecular & Cellular Medicine Board, CORE Scientific Advisory Board and many other scientific review committees.
I have been the Editor of the Nature Specialist Journal Gene Therapy since 1997, and my research into the molecular genetics of cancer and gene therapy is funded by programme grants from Cancer Research UK, Digestive Cancer Campaign and the European Union. I was elected a fellow of the Academy of Medical Sciences in 2006.
Funding
- Barts and The London Charity Strategic Grant 2009-2012 £2.95 million: Cyberknife
- Cancer Research UK Programme Grant 2009-2014 £1.2 million: Genomics & Molecular Pathology of Pancreatic Cancer
- Cancer Research UK Centre Award 2009-2012 £6 million, lead applicant with five others)
- Barts and The London Charity Strategic Grant 2009-2012 £500 K:
(with Prof Vanhaesebroeck & Dr S Joel) Proteomics technology - Barts and The London Charity Strategic Grant 2009-2012 £500 K: Professorial Unit in Male Genitourinary Oncology
- Orchid Charity Strategic Grant 2009-2014 £500 K: Professorial Unit in Male Genitourinary Oncology
- CR-UK/DoH Experimental Cancer Medicine Centre 2007-2012 £1.7 million, (with Prof J Gribben)
- Charitable Foundation of Barts & The London 2005-2011 £640 K:
- Flavell Programme for Prostate Cancer Gene Therapy
Key Publications
Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Harada T, Chelala C, Bhakta V, Chaplin T, Caulee K, Baril P, Young BD, Lemoine NR. Oncogene. 2008 Mar 20;27(13):1951-60. PMID: 17952125
PRSS3 promotes tumour growth and metastasis of human pancreatic cancer. Guozhong Jiang, Fengyu Cao, Guoping Ren, Dongling Gao, Vipul Bhakta, Yunhan Zhang, Hua Cao, Ziming Dong,; Weidong Zang, Shuijun Zhang, Han Hsi Wong, Crispin Hiley, Tatjana Crnogorac-Jurcevic, Nick R Lemoine*, Yaohe Wang. Gut. 2010 Nov;59(11):1535-44. PMID: 20947888
CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells. Wang Y, Gangeswaran R, Zhao X, Wang P, Tysome J, Bhakta V, Yuan M, Chikkanna-Gowda CP, Jiang G, Gao D, Cao F, Francis J, Yu J, Liu K, Yang H, Zhang Y, Zang W, Chelala C, Dong Z, Lemoine N. J Clin Invest. 2009 Jun;119(6):1604-15. PMID: 19411761
Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant in prostate and pancreatic cancers. Oberg D, Yanover E, Adam V, Sweeney K, Costas C, Lemoine NR, Halldén G. Clin Cancer Res. 2010 Jan 15;16(2):541-53. PMID: 20068104
Further Publications
For additional publications, please click here.
Research Group
Professor Nick Lemoine's Research Groups:
Genomics & Molecular Pathology Team:
- Dr Tatjana Crnogorac-Jurcevic, Senior Lecturer
- Dr Claude Chelala, Lecturer in Cancer Bioinformatics
- Dr Ros Cutts Bioinformatician
- Dr Jun Wang Bioinformatician
- Dr Laurent Dumartin Postdoctoral Research Fellow
- Ms Emanuela Gadaleta PhD Student
Gene Therapy Team:
- Dr Gunnel Hallden, Senior Lecturer
- Dr Yaohe Wang, Senior Lecturer
- Dr Rathi Gangeswaran, Research Associate
- Dr Ming Yuan Senior Postdoctoral Research Fellow
- Dr Louisa Chard Postdoctoral Research Fellow
- Dr Guozhong Jiang Postdoctoral Research Fellow
- Dr Mark Ferguson Clinical Research Fellow
- Dr Jonathan Hughes Clinical Research Fellow
- Dr Mohiemen Anwar Clinical Research Fellow
- Mr Vipul Bhakta Senior Scientific Officer
External Activities
Director of the NIHR Comprehensive Clinical Research Network for Central and East London
National and International Committees (current):
- British Society of Gene Therapy Executive Committee
- International Cancer Genome Consortium (ICGC) Scientific Advisory Committee
- Canadian Institute of Health Research Training Program in Molecular Pathology of Cancer Scientific Advisory Board,
- Portuguese Foundation for Science & Technology Scientific Advisory Board
- Institute of Molecular Medicine (Lisbon) Scientific Advisory Committee
- Hong Kong Research Grants Council (Biology & Medicine Panel)
- Chair, Pancreatic Cancer Research Fund Scientific Advisory Board
- Co-Chair, Pancreatic Cancer UK Charity Scientific Advisory Board
- North-East Thames Advisory Committee on Clinical Excellence Awards
Trusteeship:
- Trustee, Medical Research Foundation (MRC’s independently managed charity)
External Scientific Activities:
- Visiting Professor of Molecular Oncology, Zhengzhou University, China
- VCN Biosciences (Barcelona), Scientific Advisory Board
- Source Bioscience plc, Scientific Advisory Board
- Alexis Biotechnology Ltd, Scientific Advisory Board
Editorial Activities:
- Editor in Chief of Gene Therapy (Nature Specialist Journals) 1997-
- Commissioning Editor of British Medical Bulletin
- Science Advisory Board:
- Imperial College Press
- Journal of Pathology
- Editorial Board (current):
- Disease Models & Mechanisms
- Future Oncology
- Pancreatology;
- Encyclopedia of the Human Genome
- Current Opinion in Molecular Therapeutics
