Dr Trevor Graham

Dr Trevor Graham

MSc, MRes, PhD
Centre: Tumour Biology
Lecturer in Tumour Biology
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QMUL Directory


My lab measures the patterns of clonal evolution that define carcinogenesis and develops novel mathematical tools for analysis and prediction.

By characterising tumour evolution, we aim to find better ways to determine prognosis and more effective ways to treat cancers.

Research Details

The central themes of my lab are:

1. Characterising intra-tumour heterogeneity and using it to predict prognosis

2. Measuring the rate of evolution in premalignant lesions and using these measures to determine cancer risk.

3. Understanding how the clonal structure of tissues (particularly in the GI tract) shape patterns of somatic evolution.

The major tools of the lab are a combination of mathematical modelling, statistical inference and detailed genetic analysis.

Profile

I originally trained as a mathematician (MSci Mathematics, Imperial College, 2002) before spending time in a cancer genetics lab as part of my interdisciplinary PhD (PhD Mathematical Biology, UCL, 2009). As a postdoc, I worked in Nick Wright's lab at the Cancer Research UK London Research Institute studying clonal expansions in human tissues (2008-2011), and Carlo Maley’s lab at UCSF looking at the pattern of clonal evolution in human cancers (2011-2013).

I joined BCI in September 2013.

Funding

2015 - 2017 Crohns and Colitis UK “Molecular characterisation of inflammatory bowel disease associated neoplasia”
(current) £120,000
2015 - 2018 Barts Charity Large Project Grant: “Derivation of evolutionary biomarkers for cancer risk prediction in Ulcerative Colitis”
£464,788
2015 – 2021 Cancer Research UK Career Development Award: Quantification of human colorectal cancer evolution: initiation, progression, metastasis and response to treatment”
£1,016,947.63
2013 Willoughby Trustees Professor Derek Willoughby PhD Fund for Inflammatory Research
£172,777
2013 Barts Cancer Institute Early Career Researcher award

Key Publications

Identification of neutral tumour evolution across cancer types. Williams M*, Werner B*, Barnes C, Graham TA, Sottoriva A. Nature Genetics, 2016, e-pub ahead of print. PMID: 26780609

Pan-Cancer Analysis of the Causes and Consequences of Intra-Tumor Heterogeneity. Andor N, Graham TA, Jansen M, Aktipis CA, Petritisch C, Ji HP, Maley CC. Nature Medicine, 2015, advance online publication

A Big Bang model of human colorectal tumor growth. Sottoriva A, Kang H, Ma Z, Graham TA, Siegmund K, Press MF, Shibata D, Curtis C. Nature Genetics, 2015, 47 209–216. PMID: 25665006

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon. Baker AM, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G, McDonald SAC, Wright NA, Simons BB, Jansen M, Graham TA. Cell Reports, August 2014, 8:4 940-947. PMID: 25127143


Further Publications

 

For additional publications, please click here


My lab measures the patterns of clonal evolution that define carcinogenesis and develops novel mathematical tools for analysis and prediction.

By characterising tumour evolution, we aim to find better ways to determine prognosis and more effective ways to treat cancers.

External Activities

  • Faculty of gastrointestinal cancer section of F1000.com
  • Evolution lead for the colorectal cancer domain (GeCIP) of Genomics England
  • Member of Critical Gaps in Bowel Cancer Research working group

News

  • January 2016: Nature Genetics publication on natural law behind tumour evolution
  • July 2015: CRUK career development award for the study of human colorectal cancer evolution
  • April 2015: Barts Charity grant awarded to study IBD and cancer risk
  • April 2015: Organiser of mini-symposium Inferring Cancer Evolution from Genomic Data, part of the Modelling Biological Evolution meeting
  • March 2015: Co-running the UK-wide specialist lymphoma consortium with Prof. Jude Fitzgibbon
  • March 2015: Dr AM Baker's work on gut stem cells published in Nature Scientific Reports
  • February 2015: Collaborative work on "big bang" model of cancer evolution published
  • February 2015: Co-organised the Mathematical Biosciences Institute (mbi) Tumour Heterogeneity & The Microenvironment meeting, Ohio
  • January 2015: Named one of 9 United European Gastroenterology 'Rising Stars' of 2015
  • August 2014: Gut stem cell "wiggle" study published in Cell Reports
  • June 2014: Invited plenary lecturer at ECMTB 2014, "Quantifying clonal evolution in the human colon" (Image)
  • November 2013: Invited speaker at the NCRI conference

Please contact me to discuss opportunities.

Further information about my lab can be found here.

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