Centre for Molecular Oncology

The main goal of our centre is to use our multi-disciplinary expertise in the molecular mechanisms of cancer to develop novel biomarkers and therapies that will improve outcomes for cancer patients.

Our themes include:

Group Leaders in the Centre


Life In The Centre

Get a sense of what life is like in the Centre:

Results and Discoveries

Molecular pathology of pancreatic, prostate and lung cancers

  • First genome-wide DNA copy number analysis in pancreatic cancer [Link]
  • First proof of concept study which demonstrated that signatures of pancreatic cancer can be detected in urine [Link]
  • First description of the role of S100 proteins in pancreatic cancer aetiology and progression [Link]
  • Description of loss of ASS expression in mesothelioma as a biomarker for sensitivity to arginine deprivation [Link]– this led to the opening of the phase I/II ADAM trial (ADI-PEG in Pleural Mesothelioma) in 2011.
  • First description of DNA polymerases as potential targets for tumours lacking mismatch repair genes MSH2 and MLH1 via synthetic lethality screening [Link]
  • First description of ability of androgens to induce prostate cancer TMPRSS2:ERG fusions in non-malignant prostate cells [Link]
  • First comparative analysis of genetic alterations in Chinese and Western prostate cancers [Link]
  • Contribution to international consortium to identify seven new prostate cancer susceptibility loci using GWAS [Link]

Gene therapy

  • First description of the importance of E3 region in activity of oncolytic adenoviruses in immunocompetent cancer models [Link]
  • Identification of role of CEACAM6 in modifying adenovirus transport [Link]
  • Description of the importance of host cell DNA damage responses in adenovirus activity [Link]

Molecular imaging

  • Opening of Cancer Research UK phase I trial of [F-18] Demobesin-4 PET imaging in prostate cancer (2010)
  • Description of the value of [F-18] FDG-PET in monitoring response to treatment in locally advanced breast cancer [Link]
  • First publication on how to conjugate chelating agents to peptides for radiolabelling and imaging [Link]

Fellowship Opportunities

We are enthusiastic about hosting prestigious UK and international Fellowships within our Centre.

Listed below are major Fellowships that are relevant and available for quality candidates. Please check carefully your eligibility against the criteria in the links. Most of these are only available to UK, EU and Commonwealth researchers. We intend to support a number of outstanding candidates through the Fellowship application process each year.

If you believe you are a potential candidate please send your CV and publication list together with an outline of your future proposal to the Centre Lead (Dr Tyson Sharp; t.sharp@qmul.ac.uk), which should be compatible with the Centre Research Interest (please also refer to individual Group Leaders' Research Interests).


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