Centre for Tumour Biology
Our centre's researchers work on different aspects of the biology of transformed cells or the stromal cells found in neoplastic foci. We bring together individuals with a diverse range of expertise in cell biology, molecular biology and pathology to form a synergistic approach to complex biological problems.
Our unifying interest is in understanding the cellular and molecular events which drive tumour progression to the malignant phenotype. We have a particular interest in understanding the nature of the “cross-talk” between epithelial cancer cells and their stromal partners during cancer evolution.
The centre is based around an open-plan laboratory to maximise the opportunity for collaboration and interaction between the different groups and group members.
We bring together research scientists and clinicians to work on the research problems, with a focus always on the validation of ideas and observations in clinically-derived material, to ensure that bench-work is oriented toward understanding a “real” phenomenon.
Group Leaders in the Centre
Dr Angus James Cameron Lecturer
Dr Kit Curtius Lecturer
Professor Trevor Graham Professor of Cancer Evolution
Dr Richard Grose Reader in Cancer Cell Biology
Professor Kairbaan Hodivala-Dilke Professor of Angiogenesis, Deputy Institute Director
Professor Louise Jones Professor of Breast Pathology
Dr Stéphanie Kermorgant Reader in Cellular Oncology
Professor Hemant Kocher Professor of Liver & Pancreas Surgery
Professor Irene Leigh Honorary Professor of Cellular and Molecular Medicine
Professor John F Marshall Professor of Tumour Biology
Dr Stuart McDonald Senior Lecturer
Dr Paulo Ribeiro Senior Lecturer
Life in the Centre
Get a sense of what life is like in the Centre:
Postdoctoral Research Assistant
Results and Discoveries
Recent publications include:
- A new model of cancer evolution - following a natural mathematical law
- Insights into the role of the kinase PKN2 in development and cancer
- Understanding stem cell behaviour in the human colon
- The importance of dose - low-doses of anti-cancer drug cilengitide promotes tumour growth. PMID: 19305413