Publications

Using flies to reveal mechanisms of cancer development- Q&A with Dr Ribeiro

Posted in General News, Interviews, Publications Published by Bethan Warman 27 February 2019

Using flies to reveal mechanisms of cancer development- Q&A with Dr Ribeiro

Dr Paulo Ribeiro is a Senior Lecturer and Group Leader in our Centre for Tumour Biology. We asked him some questions about his most recent publication, which set out to identify new regulators of cancer development using the fruit fly Drosophila as a model organism.

Tackling tumour scar tissue could be key to treating pancreatic cancer

Posted in General News, Publications Published by Administrator 11 February 2019

Tackling tumour scar tissue could be key to treating pancreatic cancer

The first study in the world to take a detailed look at scar tissue in human pancreatic cancer has revealed a range of different scar tissue types that could help clinicians predict which patients will respond best to particular treatments.

Immune cells found as accomplices in melanoma spread

Posted in General News, Publications Published by Bethan Warman 31 January 2019

Immune cells found as accomplices in melanoma spread

A new study published today in Cell has revealed that aggressive melanoma cells are able to manipulate the immune system to their advantage. As a result, immune cells that are supposed to recognise and destroy cancer cells actually behave differently and support the growth and spread of the tumour.

‘The neighbouring effect’: Centrosomal abnormalities drive invasion of surrounding cells

Posted in General News, Publications Published by Bethan Warman 19 November 2018

‘The neighbouring effect’: Centrosomal abnormalities drive invasion of surrounding cells

Centrosomal amplification, a particular change that occurs within some cancer cells, has been shown to drive the invasion of neighbouring cancer cells in a recent study by researchers from the BCI, led by Dr Susana Godinho, and the Francis Crick Institute.

Killer cell immunotherapy shows promise for advanced pancreatic cancer

Posted in General News, Publications Published by Bethan Warman 01 November 2018

Killer cell immunotherapy shows promise for advanced pancreatic cancer

A new approach to treating pancreatic cancer using 'educated killer cells' has shown promise, according to early research from the BCI. The new cell-based immunotherapy, which has not yet been tested in humans with pancreatic cancer, led to mice being completely cancer-free.

New phase 3 clinical trial using combination therapy extends survival in triple-negative breast cancer

Posted in General News, BCI on the Road, Publications Published by Bethan Warman 22 October 2018

New phase 3 clinical trial using combination therapy extends survival in triple-negative breast cancer

New research led by Barts Cancer Institute and St Bartholomew’s Hospital has provided new hope for people with an aggressive type of breast cancer. The phase 3 clinical trial has shown that by using a combination of immunotherapy and chemotherapy, the body’s own immune system can be tuned to attack triple-negative breast cancer, extending survival by up to ten months.

Immunotherapy shows promise for patients with metastatic triple-negative breast cancer

Posted in General News, Publications Published by Bethan Warman 17 October 2018

Immunotherapy shows promise for patients with metastatic triple-negative breast cancer

Immunotherapy has been shown to confer an encouraging survival benefit in patients with metastatic triple-negative breast cancer (mTNBC). The phase 1 clinical trial, led by Prof Peter Schmid, Centre Lead for BCI’s Centre for Experimental Cancer Medicine, is the first to report the long-term safety and efficacy of the drug for mTNBC, and may represent significant steps forward for treatment of this disease.

Study links widely-used drug azathioprine to skin cancers

Posted in General News, Publications Published by Bethan Warman 14 September 2018

Study links widely-used drug azathioprine to skin cancers

A drug used to treat inflammatory bowel disease and arthritis, and prevent organ rejection in transplant patients, has been identified as an important contributor to skin cancer development in a study by researchers from Queen Mary University of London, including our Barts Cancer Research UK Centre (BCC) Bioinformatics team, the University of Dundee and the Wellcome Sanger Institute.

‘Chromosomal Catastrophes’ in Colorectal Cancer

Posted in General News, Publications Published by Bethan Warman 05 September 2018

‘Chromosomal Catastrophes’ in Colorectal Cancer

Understanding how cancers develop and change over time is a big challenge. For obvious reasons, scientists can’t simply sit and watch a cancer growing in a person. Members of the Evolution and Cancer Laboratory at the BCI, including lead author Dr William Cross, were part of a collaborative team that set out to identify when particular genetic changes arise during bowel cancer development. Their findings, published in Nature Ecology & Evolution, indicated that ‘chromosomal catastrophes’ sometimes occur along the evolutionary timeline of colorectal cancer development.

SNPnexus: Assessing the impact of genetic variation

Posted in General News, Publications Published by Bethan Warman 30 August 2018

SNPnexus: Assessing the impact of genetic variation

A team of researchers from BCI’s Centre for Molecular Oncology, led by Prof Claude Chelala, have made new developments to SNPnexus- a computational tool that allows for the assessment of the functional effect of sequence variants within the genome. The team hope that the new release will facilitate the development of precision medicine, allowing for the identification of effective gene targets for therapy.

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