Publications

Killer cell immunotherapy shows promise for advanced pancreatic cancer

Posted in General News, Publications Published by Bethan Warman 01 November 2018

Killer cell immunotherapy shows promise for advanced pancreatic cancer

A new approach to treating pancreatic cancer using 'educated killer cells' has shown promise, according to early research from the BCI. The new cell-based immunotherapy, which has not yet been tested in humans with pancreatic cancer, led to mice being completely cancer-free.

New trial using combination therapy extends survival in triple-negative breast cancer

Posted in General News, BCI on the Road, Publications Published by Bethan Warman 22 October 2018

New trial using combination therapy extends survival in triple-negative breast cancer

New research led by Barts Cancer Institute and St Bartholomew’s Hospital has provided new hope for people with an aggressive type of breast cancer. The phase 3 clinical trial has shown that by using a combination of immunotherapy and chemotherapy, the body’s own immune system can be tuned to attack triple-negative breast cancer, extending survival by up to ten months.

Immunotherapy shows promise for patients with metastatic triple-negative breast cancer

Posted in General News, Publications Published by Bethan Warman 17 October 2018

Immunotherapy shows promise for patients with metastatic triple-negative breast cancer

Immunotherapy has been shown to confer an encouraging survival benefit in patients with metastatic triple-negative breast cancer (mTNBC). The phase 1 clinical trial, led by Prof Peter Schmid, Centre Lead for BCI’s Centre for Experimental Cancer Medicine, is the first to report the long-term safety and efficacy of the drug for mTNBC, and may represent significant steps forward for treatment of this disease.

Study links widely-used drug azathioprine to skin cancers

Posted in General News, Publications Published by Bethan Warman 14 September 2018

Study links widely-used drug azathioprine to skin cancers

A drug used to treat inflammatory bowel disease and arthritis, and prevent organ rejection in transplant patients, has been identified as an important contributor to skin cancer development in a study by researchers from Queen Mary University of London, including our Barts Cancer Research UK Centre (BCC) Bioinformatics team, the University of Dundee and the Wellcome Sanger Institute.

‘Chromosomal Catastrophes’ in Colorectal Cancer

Posted in General News, Publications Published by Bethan Warman 05 September 2018

‘Chromosomal Catastrophes’ in Colorectal Cancer

Understanding how cancers develop and change over time is a big challenge. For obvious reasons, scientists can’t simply sit and watch a cancer growing in a person. Members of the Evolution and Cancer Laboratory at the BCI, including lead author Dr William Cross, were part of a collaborative team that set out to identify when particular genetic changes arise during bowel cancer development. Their findings, published in Nature Ecology & Evolution, indicated that ‘chromosomal catastrophes’ sometimes occur along the evolutionary timeline of colorectal cancer development.

SNPnexus: Assessing the impact of genetic variation

Posted in General News, Publications Published by Bethan Warman 30 August 2018

SNPnexus: Assessing the impact of genetic variation

A team of researchers from BCI’s Centre for Molecular Oncology, led by Prof Claude Chelala, have made new developments to SNPnexus- a computational tool that allows for the assessment of the functional effect of sequence variants within the genome. The team hope that the new release will facilitate the development of precision medicine, allowing for the identification of effective gene targets for therapy.

Researchers identify new mechanism implicated in lung cancer progression

Posted in General News, Publications Published by Bethan Warman 07 August 2018

The impact of LIMD1 loss on tumour growth

Researchers identify new mechanism implicated in lung cancer progression

A new study performed by researchers from BCI led by Dr Tyson Sharp, Lead of the Centre for Molecular Oncology, has identified a novel mechanism implicated in the development of lung adenocarcinoma (the most common type of non-small cell lung cancer), mediated by the loss of a gene called LIMD1. The findings open a new field of research into the cause, diagnosis and prognosis of LIMD1-negative lung cancers and may aid in the development of chemotherapeutic drugs to treat this disease.

The research, published recently in EMBO Molecular Medicine, highlights a fundamental process in which LIMD1 regulates the cellular response to low oxygen levels, known as hypoxia. Hypoxia is characteristic of most solid tumours, including lung cancer, and is associated with poor patient prognosis as it makes tumours more resistant to therapy.

Uncovering the evolutionary history of IBD-associated colorectal cancer

Posted in General News, Publications Published by Bethan Warman 11 July 2018

Uncovering the evolutionary history of IBD-associated colorectal cancer

A team of researchers from the BCI, led by Prof Trevor Graham, Lead of the Evolution and Cancer Biology Laboratory, have reported the genetic events involved in the early development of bowel cancer in patients with inflammatory bowel disease (IBD). Such knowledge may be able to be exploited to design simple diagnostic tests to stratify patients with IBD at high risk of developing cancer.

IBD more than doubles an individual’s lifetime risk of developing bowel cancer, and the risk increases significantly if they have suffered with IBD for a sustained period of time. With this in mind, the study published today in Gut- performed in collaboration with researchers from St Mark’s Hospital, led by Prof Ailsa Hart, and the University of Oxford, led by Prof Simon Leedham- set out to understand the genetics of how CRC develops in people with IBD.

Research explainer: Mis-segregation of human chromosomes

Posted in General News, Publications Published by Bethan Warman 13 June 2018

Research explainer: Mis-segregation of human chromosomes

Dr Sarah McClelland from Barts Cancer Institute, Queen Mary University of London, has recently published new research in the journal Cell Reports revealing new insights into why cell division can sometimes go wrong.

In this Q & A, she explains why chromosomes can end up in the wrong places when dividing and highlights two particular chromosomes that seem to be more prone to the issue than others.

Research suggests improved detection rates are needed to maximise cancer prevention

Posted in General News, Publications Published by Bethan Warman 08 June 2018

Research suggests improved detection rates are needed to maximise cancer prevention

Current detection strategies are found to have identified only 2.6% of the BRCA gene mutation carriers in the Greater London population, according to a recent study published in the Journal of Medical genetics. The findings of the study, performed by researchers from the BCI’s Centre for Experimental Cancer Medicine, led by Dr Ranjit Manchanda, suggest that enhanced and new approaches are required to maximise the opportunity for breast and ovarian cancer prevention.

BRCA1 and BRCA2 mutations are associated with an increased risk of breast and ovarian cancer. A recent study has shown that about 72 and 69% of women who inherit a harmful mutation in the BRCA1 and BRCA2 genes, respectively, develop breast cancer by 80 years of age. Additionally, 44 and 17% of women who inherit a harmful mutation in the BRCA1 and BRCA2 genes, respectively, develop ovarian cancer by 80 years of age. Identifying mutation carriers is therefore critical to reduce the number of BRCA-associated cancers.

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