Articles tagged with: Genetics

‘Chromosomal Catastrophes’ in Colorectal Cancer

Posted in General News, Publications Published by Bethan Warman 05 September 2018

‘Chromosomal Catastrophes’ in Colorectal Cancer

Understanding how cancers develop and change over time is a big challenge. For obvious reasons, scientists can’t simply sit and watch a cancer growing in a person. Members of the Evolution and Cancer Laboratory at the BCI, including lead author Dr William Cross, were part of a collaborative team that set out to identify when particular genetic changes arise during bowel cancer development. Their findings, published in Nature Ecology & Evolution, indicated that ‘chromosomal catastrophes’ sometimes occur along the evolutionary timeline of colorectal cancer development.

SNPnexus: Assessing the impact of genetic variation

Posted in General News, Publications Published by Bethan Warman 30 August 2018

SNPnexus: Assessing the impact of genetic variation

A team of researchers from BCI’s Centre for Molecular Oncology, led by Prof Claude Chelala, have made new developments to SNPnexus- a computational tool that allows for the assessment of the functional effect of sequence variants within the genome. The team hope that the new release will facilitate the development of precision medicine, allowing for the identification of effective gene targets for therapy.

Fellows inaugurated at new Rutherford Academy of Population Genomics and Health Data Science

Posted in General News, Grants & Awards Published by Bethan Warman 16 May 2018

Fellows inaugurated at new Rutherford Academy of Population Genomics and Health Data Science

Queen Mary University of London has appointed four research fellows to its new Rutherford Academy of Population Genomics and Health Data Science, funded by the Medical Research Council and UK Research and Innovation’s Rutherford Fund. Two of the fellows include BCI’s Dr Kit Curtius and Dr Dayem Ullah.

Queen Mary’s new Rutherford Academy will be aligned to its research as a partner of the London substantive site of Health Data Research UK - a major new initiative to transform health through data science. Forty two of these prestigious fellowships were awarded following a rigorous national competition, resulting in four fellowships at Queen Mary out of a total of fourteen awarded to London universities.

London Pancreas Workshop 2018

Posted in General News, BCI Spotlight Articles, Events Published by Bethan Warman 11 May 2018

A forum for state-of-the-art clinical and basic research in pancreatic cancer

London Pancreas Workshop 2018

On Friday 4th May, BCI hosted the seventh London Pancreas Workshop, co-organised by Prof Hemant Kocher and our Director Prof Nick Lemoine, which attracted delegates from across Europe and America, with over 140 attendees in total. The biennial event is recognised as a forum for state-of-the-art clinical and basic research in pancreatic cancer.

The areas of focus for this year’s workshop were diagnostics, clinical trials and preclinical work for targeting pancreatic cancer. We heard a variety of interesting talks in these areas, delivered by researchers renowned in their fields.

Follicular lymphoma marked by spatial tumour heterogeneity

Posted in General News, Publications Published by Bethan Warman 23 March 2018

A challenge for targeted therapy

Follicular lymphoma marked by spatial tumour heterogeneity

A research team at the BCI, Queen Mary University of London, led by Dr Jessica Okosun, Centre for Haemato-Oncology, has found that tumours at different sites within the same patient with follicular lymphoma can be genetically diverse. This suggests that a sole biopsy is incapable of capturing all the genetic events in any given individual and presents a significant challenge when providing targeted therapies to treat this disease.

Follicular lymphoma is an incurable blood cancer that is characterised by the production of abnormal B lymphocytes (a type of white blood cell involved in fighting infection) that accumulate primarily in the lymph nodes and bone marrow. Approximately 2,300 cases of follicular lymphoma are diagnosed in the UK each year.

BCI at the 59th ASH Annual Meeting

Posted in General News, Conferences, BCI on the Road Published by Reza Roozitalab 08 December 2017

"The most prestigious event in the haematology calendar"

BCI at the 59th ASH Annual Meeting

Research teams from our Centre for Haemato-Oncology have once again joined the world’s most influential figures in haematology to present their cutting-edge findings at the 59th ASH Annual Meeting & Exposition.

Study sheds new light on how cancer cells adapt to become aggressive

Posted in General News, Publications Published by Reza Roozitalab 04 December 2017

Centrosome amplification: not as clear cut as once thought

Study sheds new light on how cancer cells adapt to become aggressive

A new study from Dr Susana Godinho’s lab has revealed surprising insights into how cancer cells adapt to ‘centrosome amplification’ – a mechanism that they have previously demonstrated to be essential in allowing certain tumours to become aggressive and metastatic.

Epigenetic editing: not just a one 'hit' wonder

Posted in General News, Publications Published by Reza Roozitalab 13 November 2017

New research published today in Nature Communications

Epigenetic editing: not just a one 'hit' wonder

For the very first time, researchers at BCI have shown that modifying the ‘epigenome’ of a healthy breast cell is not only possible, but precise enough to initiate a chain reaction of events that make the cell abnormal.

A New Target Linked with Several Aggressive Forms of Blood Tumour

Posted in General News, Publications Published by Reza Roozitalab 23 October 2017

Lamin B1 - a potential target for follicular lymphoma and Chronic lymphocytic leukaemia

A New Target Linked with Several Aggressive Forms of Blood Tumour

Manipulating levels of Lamin B1 may one day prove an effective treatment option for patients with lymphomas and chronic lymphocytic leukaemia...

Introducing BCI Animations - blood cancers and solid tumours

Posted in General News, Engagement Published by Zoe Leech 13 March 2017

Haemato-Oncology and Tumour Biology

Introducing BCI Animations - blood cancers and solid tumours

BCI has been working with Phospho Biomedical Animations to bring some of our key cancer research topics to life.

Watch these short videos to learn about two of our research Centres' major experimental subjects. Let us know what you think!

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