Articles tagged with: Genetics

Dr Manchanda becomes NHS Innovation Accelerator Fellow for Population-based Genetic Testing

Posted in General News, Grants & Awards Published by Bethan Warman 05 March 2019

Dr Manchanda becomes NHS Innovation Accelerator Fellow for Population-based Genetic Testing

Dr Ranjit Manchanda was announced today as one of 13 Fellows to join the NHS Innovation Accelerator (NIA), which supports dedicated individuals to scale their high impact, evidence-based innovations across the NHS and wider healthcare system.

Using flies to reveal mechanisms of cancer development- Q&A with Dr Ribeiro

Posted in General News, Interviews, Publications Published by Bethan Warman 27 February 2019

Using flies to reveal mechanisms of cancer development- Q&A with Dr Ribeiro

Dr Paulo Ribeiro is a Senior Lecturer and Group Leader in our Centre for Tumour Biology. We asked him some questions about his most recent publication, which set out to identify new regulators of cancer development using the fruit fly Drosophila as a model organism.

Genomics project reaches goal of 100,000 genomes sequenced from NHS patients

Posted in General News Published by Administrator 06 December 2018

Genomics project reaches goal of 100,000 genomes sequenced from NHS patients

UK Health Secretary Matt Hancock announced yesterday that a project involving Queen Mary University of London researchers has reached its goal of sequencing 100,000 whole genomes from NHS patients. The 100,000 Genomes Project, led by Genomics England in partnership with NHS England, is a ground-breaking programme which has been based at Queen Mary’s Charterhouse Square campus since 2013, involving 24 of its staff members.

Accelerator Award to improve early detection and intervention of blood cancers

Posted in General News, Grants & Awards Published by Bethan Warman 09 October 2018

Accelerator Award to improve early detection and intervention of blood cancers

BCI researchers are lead members of an international team to be funded by an Accelerator Award, which will bring together scientists from the UK, Spain and Italy in a bid to improve early detection and intervention of blood cancers. The award of £4.8M over 5 years, funded through a partnership between Cancer Research UK (CRUK), AIRC and FC AECC, encourages cross-institutional collaboration to unite resources and expertise to accelerate progress in cancer research.

‘Chromosomal Catastrophes’ in Colorectal Cancer

Posted in General News, Publications Published by Bethan Warman 05 September 2018

‘Chromosomal Catastrophes’ in Colorectal Cancer

Understanding how cancers develop and change over time is a big challenge. For obvious reasons, scientists can’t simply sit and watch a cancer growing in a person. Members of the Evolution and Cancer Laboratory at the BCI, including lead author Dr William Cross, were part of a collaborative team that set out to identify when particular genetic changes arise during bowel cancer development. Their findings, published in Nature Ecology & Evolution, indicated that ‘chromosomal catastrophes’ sometimes occur along the evolutionary timeline of colorectal cancer development.

SNPnexus: Assessing the impact of genetic variation

Posted in General News, Publications Published by Bethan Warman 30 August 2018

SNPnexus: Assessing the impact of genetic variation

A team of researchers from BCI’s Centre for Molecular Oncology, led by Prof Claude Chelala, have made new developments to SNPnexus- a computational tool that allows for the assessment of the functional effect of sequence variants within the genome. The team hope that the new release will facilitate the development of precision medicine, allowing for the identification of effective gene targets for therapy.

Fellows inaugurated at new Rutherford Academy of Population Genomics and Health Data Science

Posted in General News, Grants & Awards Published by Bethan Warman 16 May 2018

Fellows inaugurated at new Rutherford Academy of Population Genomics and Health Data Science

Queen Mary University of London has appointed four research fellows to its new Rutherford Academy of Population Genomics and Health Data Science, funded by the Medical Research Council and UK Research and Innovation’s Rutherford Fund. Two of the fellows include BCI’s Dr Kit Curtius and Dr Dayem Ullah.

Queen Mary’s new Rutherford Academy will be aligned to its research as a partner of the London substantive site of Health Data Research UK - a major new initiative to transform health through data science. Forty two of these prestigious fellowships were awarded following a rigorous national competition, resulting in four fellowships at Queen Mary out of a total of fourteen awarded to London universities.

London Pancreas Workshop 2018

Posted in General News, BCI Spotlight Articles, Events Published by Bethan Warman 11 May 2018

A forum for state-of-the-art clinical and basic research in pancreatic cancer

London Pancreas Workshop 2018

On Friday 4th May, BCI hosted the seventh London Pancreas Workshop, co-organised by Prof Hemant Kocher and our Director Prof Nick Lemoine, which attracted delegates from across Europe and America, with over 140 attendees in total. The biennial event is recognised as a forum for state-of-the-art clinical and basic research in pancreatic cancer.

The areas of focus for this year’s workshop were diagnostics, clinical trials and preclinical work for targeting pancreatic cancer. We heard a variety of interesting talks in these areas, delivered by researchers renowned in their fields.

Follicular lymphoma marked by spatial tumour heterogeneity

Posted in General News, Publications Published by Bethan Warman 23 March 2018

A challenge for targeted therapy

Follicular lymphoma marked by spatial tumour heterogeneity

A research team at the BCI, Queen Mary University of London, led by Dr Jessica Okosun, Centre for Haemato-Oncology, has found that tumours at different sites within the same patient with follicular lymphoma can be genetically diverse. This suggests that a sole biopsy is incapable of capturing all the genetic events in any given individual and presents a significant challenge when providing targeted therapies to treat this disease.

Follicular lymphoma is an incurable blood cancer that is characterised by the production of abnormal B lymphocytes (a type of white blood cell involved in fighting infection) that accumulate primarily in the lymph nodes and bone marrow. Approximately 2,300 cases of follicular lymphoma are diagnosed in the UK each year.

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