Articles tagged with: Lung

Researchers identify new mechanism implicated in lung cancer progression

Posted in General News, Publications Published by Bethan Warman 07 August 2018

The impact of LIMD1 loss on tumour growth

Researchers identify new mechanism implicated in lung cancer progression

A new study performed by researchers from BCI led by Dr Tyson Sharp, Lead of the Centre for Molecular Oncology, has identified a novel mechanism implicated in the development of lung adenocarcinoma (the most common type of non-small cell lung cancer), mediated by the loss of a gene called LIMD1. The findings open a new field of research into the cause, diagnosis and prognosis of LIMD1-negative lung cancers and may aid in the development of chemotherapeutic drugs to treat this disease.

The research, published recently in EMBO Molecular Medicine, highlights a fundamental process in which LIMD1 regulates the cellular response to low oxygen levels, known as hypoxia. Hypoxia is characteristic of most solid tumours, including lung cancer, and is associated with poor patient prognosis as it makes tumours more resistant to therapy.

International Clinical Trials Day 2018

Posted in General News Published by Bethan Warman 21 May 2018

International Clinical Trials Day 2018

International Clinical Trials Day is celebrated on 20th May each year in recognition of the clinical trials conducted around the world, which ensure that research from the laboratory can be translated into patient benefit. The progress that is continuing to be made in cancer research, resulting in cancer survival rates doubling in the last 40 years, would not be possible without the researchers, clinicians, nurses and, of course, patients that are involved in clinical trials each year.

RECRUITING: ATOMIC-meso, a Global Randomised Trial of Triplet Drug Therapy for Malignant Mesothelioma

Posted in General News Published by Reza Roozitalab 19 October 2017

ADI-PEG20 continues to show promise

RECRUITING: ATOMIC-meso, a Global Randomised Trial of Triplet Drug Therapy for Malignant Mesothelioma

Several ongoing clinical trials, led by Dr Peter Szlosarek at the Barts Cancer Centre, continue to investigate the clinical efficacy of "arginine starvation" using ADI-PEG20...

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