Articles tagged with: Microenvironment

Immune cells found as accomplices in melanoma spread

Posted in General News, Publications Published by Bethan Warman 31 January 2019

Immune cells found as accomplices in melanoma spread

A new study published today in Cell has revealed that aggressive melanoma cells are able to manipulate the immune system to their advantage. As a result, immune cells that are supposed to recognise and destroy cancer cells actually behave differently and support the growth and spread of the tumour.

‘The neighbouring effect’: Centrosomal abnormalities drive invasion of surrounding cells

Posted in General News, Publications Published by Bethan Warman 19 November 2018

‘The neighbouring effect’: Centrosomal abnormalities drive invasion of surrounding cells

Centrosomal amplification, a particular change that occurs within some cancer cells, has been shown to drive the invasion of neighbouring cancer cells in a recent study by researchers from the BCI, led by Dr Susana Godinho, and the Francis Crick Institute.

BCI welcomes two new Group Leaders

Posted in General News Published by Bethan Warman 07 November 2018

BCI welcomes two new Group Leaders

We are pleased to welcome two new members of academic staff to the BCI- Professor Victoria Sanz-Moreno, joining us from King’s College, London, and Professor Kamil R Kranc, joining us from the University of Edinburgh.

Researchers identify new mechanism implicated in lung cancer progression

Posted in General News, Publications Published by Bethan Warman 07 August 2018

The impact of LIMD1 loss on tumour growth

Researchers identify new mechanism implicated in lung cancer progression

A new study performed by researchers from BCI led by Dr Tyson Sharp, Lead of the Centre for Molecular Oncology, has identified a novel mechanism implicated in the development of lung adenocarcinoma (the most common type of non-small cell lung cancer), mediated by the loss of a gene called LIMD1. The findings open a new field of research into the cause, diagnosis and prognosis of LIMD1-negative lung cancers and may aid in the development of chemotherapeutic drugs to treat this disease.

The research, published recently in EMBO Molecular Medicine, highlights a fundamental process in which LIMD1 regulates the cellular response to low oxygen levels, known as hypoxia. Hypoxia is characteristic of most solid tumours, including lung cancer, and is associated with poor patient prognosis as it makes tumours more resistant to therapy.

Pancreatic Cancer UK Grand Challenge

Posted in General News, Grants & Awards Published by Bethan Warman 27 July 2018

PCUK’s largest ever research fund

Pancreatic Cancer UK Grand Challenge

Our Director, Prof Nicholas Lemoine, and a team of researchers from the BCI and King’s College London have been awarded the Pancreatic Cancer UK (PCUK) Grand Challenge- PCUK’s largest ever research fund. The grant will be used for the development of a type of immunotherapy, known as CAR-T cell therapy, to treat pancreatic cancer.

Immunotherapy harnesses the body’s own immune system to identify and kill cancer cells, and has been demonstrated to be an effective treatment option in a variety of cancer types. In CAR-T cell therapy, T cells- key immune cells responsible for fighting infected cells- are isolated from patient blood samples, modified outside of the body and reinjected back into the patient. Once back in the body, the T cells are equipped to target and attack tumours.

London Pancreas Workshop 2018

Posted in General News, BCI Spotlight Articles, Events Published by Bethan Warman 11 May 2018

A forum for state-of-the-art clinical and basic research in pancreatic cancer

London Pancreas Workshop 2018

On Friday 4th May, BCI hosted the seventh London Pancreas Workshop, co-organised by Prof Hemant Kocher and our Director Prof Nick Lemoine, which attracted delegates from across Europe and America, with over 140 attendees in total. The biennial event is recognised as a forum for state-of-the-art clinical and basic research in pancreatic cancer.

The areas of focus for this year’s workshop were diagnostics, clinical trials and preclinical work for targeting pancreatic cancer. We heard a variety of interesting talks in these areas, delivered by researchers renowned in their fields.

Seema Jaswal visits the BCI

Posted in General News, Engagement Published by Bethan Warman 15 March 2018

Celebrating International Women's Day

Seema Jaswal visits the BCI

Last Thursday was International Women’s Day- a day that celebrates the social, political, cultural and economic achievements of women from all over the world. Recently, an inspirational woman, Seema Jaswal- a television and radio presenter- visited us here at the Barts Cancer Institute (BCI) to meet some of our researchers and find out more about the cutting edge research that goes on here.

Seema’s TV career began at Sky Sports where she worked as a Runner before receiving her first presenting job on CBBC Sports Round. Seema’s successful career has since seen her host a variety of events, including the Indian Super League, India’s FIFA U17 World Cup and the Premier League. Last year, Seema was named as one of We Are The City’s Inspirational Women.

The involvement of the microenvironment in tumour evolution

Posted in General News, Publications Published by Bethan Warman 15 February 2018

Understanding the relationship between tumours and their environment

The involvement of the microenvironment in tumour evolution

For the first time, researchers at the Barts Cancer Institute (BCI), Queen Mary University of London, have profiled what happens at the site of tumour metastasis as cancer grows and develops. By looking closely at the tumour microenvironment (TME), the team led by Professor Fran Balkwill, Lead for the Centre for Cancer & Inflammation, has identified changes that occur as a type of ovarian cancer evolves.

By analysing samples from the omentum- the most common site for cancer spread in high-grade serous ovarian cancer (HGSOC)- from 36 women with differing degrees of disease severity, the team have gained a comprehensive understanding of the relationship between tumours and their environment during the progression of this type of ovarian cancer.

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