Articles tagged with: Ovarian

Research suggests improved detection rates are needed to maximise cancer prevention

Posted in General News, Publications Published by Bethan Warman 08 June 2018

Research suggests improved detection rates are needed to maximise cancer prevention

Current detection strategies are found to have identified only 2.6% of the BRCA gene mutation carriers in the Greater London population, according to a recent study published in the Journal of Medical genetics. The findings of the study, performed by researchers from the BCI’s Centre for Experimental Cancer Medicine, led by Dr Ranjit Manchanda, suggest that enhanced and new approaches are required to maximise the opportunity for breast and ovarian cancer prevention.

BRCA1 and BRCA2 mutations are associated with an increased risk of breast and ovarian cancer. A recent study has shown that about 72 and 69% of women who inherit a harmful mutation in the BRCA1 and BRCA2 genes, respectively, develop breast cancer by 80 years of age. Additionally, 44 and 17% of women who inherit a harmful mutation in the BRCA1 and BRCA2 genes, respectively, develop ovarian cancer by 80 years of age. Identifying mutation carriers is therefore critical to reduce the number of BRCA-associated cancers.

Dr Ranjit Manchanda awarded William Blair Bell Memorial Lecture

Posted in General News, Grants & Awards Published by Bethan Warman 09 March 2018

A prestigious prize awarded by the Royal College of Obstetricians and Gynaecologists

Dr Ranjit Manchanda awarded William Blair Bell Memorial Lecture

Congratulations to our Dr Ranjit Manchanda, Centre for Experimental Cancer Medicine, who has been awarded the William Blair Bell Memorial Lecture prize. Dr Ranjit Manchanda was awarded with the prize on 8th February and presented his lecture, entitled ‘Population based germline testing and targeted ovarian cancer prevention,’ the following day.

Dr Manchanda said: "It is an honour to have received this prestigious prize. I am humbled by this recognition and will work tirelessly to further this research which I strongly believe will bring about a new paradigm for preventing cancers and saving lives."

The involvement of the microenvironment in tumour evolution

Posted in General News, Publications Published by Bethan Warman 15 February 2018

Understanding the relationship between tumours and their environment

The involvement of the microenvironment in tumour evolution

For the first time, researchers at the Barts Cancer Institute (BCI), Queen Mary University of London, have profiled what happens at the site of tumour metastasis as cancer grows and develops. By looking closely at the tumour microenvironment (TME), the team led by Professor Fran Balkwill, Lead for the Centre for Cancer & Inflammation, has identified changes that occur as a type of ovarian cancer evolves.

By analysing samples from the omentum- the most common site for cancer spread in high-grade serous ovarian cancer (HGSOC)- from 36 women with differing degrees of disease severity, the team have gained a comprehensive understanding of the relationship between tumours and their environment during the progression of this type of ovarian cancer.

Cost-effective testing for breast and ovarian cancer gene mutations

Posted in General News, Publications Published by Bethan Warman 18 January 2018

Cost-effective testing for breast and ovarian cancer gene mutations

Screening the entire population for breast and ovarian cancer gene mutations, as opposed to just those at high-risk of carrying this mutation, is cost effective and could prevent more ovarian and breast cancers than the current approach, according to research led by Barts Cancer Institute of Queen Mary University of London.

The researchers believe that implementing a programme to test all British women over 30 years of age could result in thousands of fewer cases of ovarian and breast cancer; up to 17,000 fewer ovarian cancers and 64,000 fewer breast cancers over a lifetime.

New Group Leaders at BCI

Posted in General News Published by Reza Roozitalab 16 October 2017

New and familiar faces at Barts Cancer Institute

New Group Leaders at BCI

Congratulations to academic staff members Dr Jessica Okosun & Kevin Rouault-Pierre from our Centre for Haematology Oncology and Dr Oliver Pearce from the Centre for Cancer & Inflammation! 

Find out more about the research that our new group leaders will carry out...

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