Articles tagged with: Prostate

London leads the way in advanced prostate cancer research

Posted in General News, Grants & Awards Published by Administrator 25 January 2019

London leads the way in advanced prostate cancer research

Dr Gunnel Halldén is leading a new pioneering study funded by Prostate Cancer UK, as part of the charity’s Research Innovation Awards scheme.

Using a modified adenovirus to overcome treatment resistance in prostate cancer

Posted in General News, Publications Published by Bethan Warman 27 April 2018

Using a modified adenovirus to overcome treatment resistance in prostate cancer

Researchers from BCI’s Centre for Molecular Oncology, led by Dr Gunnel Halldén, have identified a mechanism by which a modified flu-like virus, called AdDD, is able to negate resistance to a drug called mitoxantrone and increase tumour cell killing in prostate cancer models. This mechanism is dependent on B-cell lymphoma 2 (Bcl-2)- a protein involved in the regulation of cell death (apoptosis).

Recent statistics have shown that prostate cancer is now the third biggest cancer killer in the UK, claiming the life of one man every 45 minutes. Here at the BCI, prostate cancer is a key focus of research and our researchers endeavour to identify factors that influence prostate cancer progression and therapeutic response.

BCI and KCL collaboration develops a clinically-relevant CAR-T cell imaging system

Posted in General News, Publications Published by Bethan Warman 19 April 2018

BCI and KCL collaboration develops a clinically-relevant CAR-T cell imaging system

A collaboration involving researchers from BCI’s Centre for Molecular Oncology, led by Dr Jane Sosabowski, and the ImmunoEngineering Group of King’s College London (KCL), led by Dr Sophie Papa, has developed an effective and clinically-relevant imaging system to monitor chimeric antigen receptor (CAR)-T cells within the body. This system reduced the tumour burden in a pre-clinical model of prostate cancer and allowed for repeated and non-invasive assessment of CAR-T cell localisation.

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