PhD Students: Bakhouche Bakhouche & Paul Grevitt

Thu. 8 Jun, 2017 12:30 pm - 1:30 pm
Thu. 8 Jun, 2017 12:30 pm - 1:30 pm
This event does not repeat

For this instalment of the BCI's Seminar Series, we are pleased to welcome two of BCI's PhD students to present:

  • Bakhouche Bakhouche - Centre for Tumour Biology

Bakhouche's talk is entitled: 'Location matters: The role of c-Met endosomal signalling in pancreatic cancer cell migration'

  • Paul Grevitt - Centre for Molecular Oncology

Paul's talk is entitled: 'Identification of novel regulators of HIFs'

This will be held in the Lister and Young Seminar Room, from 12.30pm-1.30pm.

PhD Students: Mary-Kate Hayward & Ming-Hsin Yang

Thu. 15 Jun, 2017 12:30 pm - 1:30 pm
Thu. 15 Jun, 2017 12:30 pm - 1:30 pm
This event does not repeat

As part of the BCI's Seminar Series, we are pleased to welcome two of BCI's PhD students to present.

  • Mary-Kate Hayward - Centre for Tumour Biology
  • Ming-Hsin Yang - Centre for Stem Cells in Cancer and Ageing

This will be held in the Lister and Young Seminar Room, from 12.30pm-1.30pm.

PhD Students: Eleonora Li Causi & Viola Walther

Thu. 22 Jun, 2017 12:30 pm - 1:30 pm
Thu. 22 Jun, 2017 12:30 pm - 1:30 pm
This event does not repeat

We are pleased to welcome two of BCI's PhD students to present for this instalment of the BCI's Seminar Series.

  • Eleonora Li Causi - Centre for Cancer and Inflammation

Eleonora's title is entitled: "The role of CX3CR1 in Pancreatic cancer"

  • Viola Walther - Centre for Tumour Biology

Viola's title is entitled: "Clonal Interactions as Mechanisms of Polyclonality in Colorectal Adenomas"

This will be held in the Lister and Young Seminar Room, from 12.30pm-1.30pm.

Professor Zongbing You

Thu. 22 Jun, 2017 1:30 pm - 2:30 pm
Thu. 22 Jun, 2017 1:30 pm - 2:30 pm
This event does not repeat

As part of the BCI's Thursday Seminar Series, we are pleased to welcome Professor Zongbing You from Tulane University School of Medicine, New Orleans. His team has focused on understanding the role of inflammation in cancer initiation, promotion, and progression, in particular in interleukin-17 (IL-17) pathway in prostate cancer. For more information, please click here

The title of his talk will be: IL-17-MMP7-EMT Axis as Potential Druggable Target in the Prevention and Treatment of Prostate Cancer.

This will be held in the Lister and Young Seminar room from 1.30pm - 2.30pm.

Ramesh Arasaradnam

Thu. 29 Jun, 2017 12:30 pm - 1:30 pm
Thu. 29 Jun, 2017 12:30 pm - 1:30 pm
This event does not repeat

As part of the BCI's Seminar Series, we are pleased to welcome Professor Ramesh Arasaradnam from the University of Warwick to present. Ramesh's research interests are focused in gut physiology, nutrition, inflammatory and cancer biology.

This will be held in the Lister and Young Seminar Room, 12.30pm-1.30pm.

Rita Sousa-Nunes

Thu. 6 Jul, 2017 12:30 pm - 1:30 pm
Thu. 6 Jul, 2017 12:30 pm - 1:30 pm
This event does not repeat

We are pleased to welcome Rita Sousa-Nunes from King's College London to present. Rita's research group are interested in neural proligeration and how its disruption can lead to immortal and invasive tumours. More information about her work can be found here.

This will be held in the Lister and Young Seminar Room, from 12.30pm-1.30pm.

Thursday Seminar Series – Dr Alexey Danilov from OHSU Knight Cancer Institute, USA – 21st September

Thu. 21 Sep, 2017 12:30 pm - 1:30 pm
Thu. 21 Sep, 2017 12:30 pm - 1:30 pm
This event does not repeat

As part of the BCI's Seminar Series, we are pleased to welcome Dr Alexey Danilov from OHSU Knight Cancer Institute, USA to present. The Danilov Lab focuses on understanding the signalling pathways which underlie survival of lymphoma cells in their protective microenvironment-lymph nodes and bone marrow. For more information about Dr Danilov's work, please click here

The title of Dr Danilov's talk will be: "Targeting TNF receptor signaling to potentiate inhibition of B-cell receptor-associated kinases in B-cell malignancies"

If you would like to talk with Dr Alexey Danilov, please contact Sergey Krysov (s.krysov@qmul.ac.uk

This will be held in the L&Y Seminar Room, from 12.30pm - 1.30pm.

Thursday Seminar Series – Dr Jamie Blundell from University of Cambridge, 12th October

Thu. 12 Oct, 2017 12:30 pm - 1:30 pm
Thu. 12 Oct, 2017 12:30 pm - 1:30 pm
This event does not repeat

As part of the BCI's Seminar Series, we are pleased to welcome Dr Jamie Blundell from University of Cambrdige to present. Jamie Blundell is a group leader in the dept of Oncology in Cambridge. His elegant works combines genetic lineage tracing and mathematical theory to track and predict clonal evolution, with the goal of cancer early detection. For more information about Dr Blundell's work, please click here 

The title of Dr Blundell's talk will be: "Quantitative evolutionary dynamics: combining theory and experiment to understand asexual evolution"

Some of his latest papers can be found below: 

http://www.nature.com/nature/journal/v519/n7542/abs/nature14279.html

https://doi.org/10.1016/j.cell.2016.08.002 

http://www.biorxiv.org/content/early/2017/07/31/170589 

If you would like to meet with Dr Blundell during his visit, please contact Trevor Graham (t.graham@qmul.ac.uk

This will be held in the L&Y Seminar Room, from 12.30pm - 1.30pm.

Thursday Seminar Series - Hannah Shailes (Molecular Oncology) - 26th October

Thu. 26 Oct, 2017 12:30 pm - 1:30 pm
Thu. 26 Oct, 2017 12:30 pm - 1:30 pm
This event does not repeat

For this instalment of the BCI's Thursday Seminar Series, we are pleased to welcome one of BCI's PhD students to present:

  • Hannah Shailes - Centre for Molecular Oncology

Hannah's talk is entitled: 'Targeting APC using synthetic lethality in Colorectal Cancer'

This will be held from 12.30 - 13.30pm in the L&Y Seminar Room.

Thursday Seminar Series

Thu. 2 Nov, 2017 12:30 pm - 1:30 pm
Thu. 2 Nov, 2017 12:30 pm - 1:30 pm
This event does not repeat

As part of the BCI's Seminar Series, we are pleased to welcome Dr Dan Tennant from University of Birmingham to present at the BCI. More information about Dr Tennant's research can be found here

The seminar is entitled: 'Investigating hypoxic metabolism through the analysis of reductionist genetic models'

Abstract: Low oxygen tension (hypoxia), is a common and pernicious tumour-associated phenotype that arises from an absent, or poorly-formed vasculature. Hypoxic regions of tumours contain some of the most therapy resistant cells; the greater the extent and severity of hypoxia the worse the overall survival of patients. New therapeutic approaches that can selectively target these cells would therefore likely improve patient outcomes. Much of the metabolic network within cells requires oxygen for normal function, so survival in these conditions requires a change in pathway usage, which can reveal hypoxia-specific vulnerabilities that may be therapeutically tractable. I will discuss the research in my group using stable isotope-enriched nutrient tracing to identify metabolic enzymes that represent vulnerabilities in hypoxic cancer cells, and in particular the use of genetic models that recapitulate aspects of the hypoxic phenotype in normoxic conditions as tools to more rapidly and accurately identify the most suitable candidate enzymes.

The seminar will be held in the Lister and Young Seminar Room, 12.30pm - 13.30pm.

If you would like to arrange to talk with Dr Tennant, please contact Sara Muradi (s.muradi@qmul.ac.uk

Thursday Seminar Series

Thu. 9 Nov, 2017 12:30 pm - 1:30 pm
Thu. 9 Nov, 2017 12:30 pm - 1:30 pm
This event does not repeat

As part of the BCI's Thursday Seminar Series, we are pleased to welcome Dr Kevin Myant from University of Edinburgh to present on Thursday 9th November. For more information about Dr Myant's work, please click here 

The title of Dr Myant's talk will be: "The role of dysregulated RNA splicing in colon cancer initiation"

If you would like to meet with Dr Myant during his visit, please contact Prabs (p.rajan@qmul.ac.uk

This will be held in the L&Y Seminar Room, from 12.30pm - 1.30pm.

Thursday Seminar Series – Dr Mariona Graupera from Bellvitge Biomedical Research Institute (IDIBELL), 23rd November

Thu. 23 Nov, 2017 12:30 pm - 1:30 pm
Thu. 23 Nov, 2017 12:30 pm - 1:30 pm
This event does not repeat

As part of the BCI's Seminar Series, we are pleased to welcome Dr Mariona Graupera from Bellvitge Biomedical Research Institute (IDIBELL) to present at the BCI on Thursday 23rd November. More information about Dr Graupera's research can be found here

The seminar is entitled: 'PI3Ka and blood vessels: a love story'

The seminar will be held in the Lister and Young Seminar Room, 12.30pm - 13.30pm.

If you would like to arrange to talk with Dr Graupera, please contact Kebs (k.hodivala-dilke@qmul.ac.uk

Thursday Seminar Series – Dr Sam Au from Imperial College London, Thursday 30th November

Thu. 30 Nov, 2017 12:30 pm - 1:30 pm
Thu. 30 Nov, 2017 12:30 pm - 1:30 pm
This event does not repeat

On Thursday 30th November we are happy to welcome Dr Sam Au from Imperial College London to present at the BCI. More information about Dr Au's research can be found here

The seminar is entitled: 'Microfluidics for the Investigation and Isolation of Circulating Tumour Cell Clusters'

The seminar will be held in the Lister and Young Seminar Room, 12.30pm - 13.30pm.

If you would like to arrange to talk with Dr Au, please contact Yong-Jie Lu (y.j.lu@qmul.ac.uk

Thursday Seminar Series - Will Jones (Molecular Oncology) - 14th December

Thu. 14 Dec, 2017 12:30 pm - 1:30 pm
Thu. 14 Dec, 2017 12:30 pm - 1:30 pm
This event does not repeat

For this instalment of the BCI's Thursday Seminar Series, we are pleased to welcome one of BCI's PhD students to present.

  • Will Jones - Centre for Molecular Oncology

Will's talk is entitled: ‘IκB Kinase ε couples innate immunity with aerobic glycolysis and serine metabolism in breast cancer cells’

This will be held from 12.30pm - 1.30pm in the L&Y Seminar Room.

Special Seminar - Dr Sophie Acton - Thursday 11th January

Thu. 11 Jan, 2018 12:30 pm - 1:30 pm
Thu. 11 Jan, 2018 12:30 pm - 1:30 pm
This event does not repeat

On Thursday 11th January, we are pleased to welcome Dr Sophie Acton from University College London to present at the BCI. More information about Dr Acton's research can be found here

The seminar is entitled: 'Leukocyte control of fibroblast function - extracellular matrix and lymph node remodeling'

The seminar will be held in the Lister and Young Seminar Room, 12.30 - 13.30pm

If you would like to arrange to speak with Dr Acton, please contact Nick Summerfield (n.summerfield@qmul.ac.uk)

Special Seminar – Dr Aga Gambus – Thursday 18th January

Thu. 18 Jan, 2018 12:30 pm - 1:30 pm
Thu. 18 Jan, 2018 12:30 pm - 1:30 pm
This event does not repeat

On Thursday 18th January, we are pleased to welcome Dr Aga Gambus from University of Birmingham to present at the BCI. More information about Dr Gambus' research can be found here

The seminar is entitled: "The mechanism and importance of replication machinery unloading"

The seminar will be held in the Lister and Young Seminar Room, 12.30 - 13.30pm

If you would like to arrange to speak with Dr Gambus, please contact Kebs (k.hodivala-dilke@qmul.ac.uk

Special Seminar – Dr Ping-Chih Ho – Wednesday 24th January

Wed. 24 Jan, 2018 1:30 pm - 2:30 pm
Wed. 24 Jan, 2018 1:30 pm - 2:30 pm
This event does not repeat

On Wednesday 24th January, we are pleased to welcome Dr Ping-Chih Ho from University of Lausanne to present at the BCI. More information about Dr Ho's research can be found here

The seminar is entitled: 'You are fired up! Metabolic intervention and beyond for cancer immunotherapy'

The seminar will be held in the Lister and Young Seminar Room, 13.30pm - 14.30pm 

If you would like to arrange to speak with Dr Ho, please contact Nick Summerfield (n.summerfield@qmul.ac.uk

Thursday Seminar Series - Dr Sandra Blanco from CIC bioGUNE in Bilbao, Spain - 25th January

Thu. 25 Jan, 2018 12:30 pm - 1:30 pm
Thu. 25 Jan, 2018 12:30 pm - 1:30 pm
This event does not repeat

As part of the BCI's Seminar Series, we are pleased to welcome Dr Sandra Blanco from CIC bioGUNE in Bilbao, Spain to present at the BCI on Thursday 25th January.

The seminar is entitled: 'The emerging complexity of the RNA world'

Epigenetic modifications are well known to induce changes in gene expression regulation that are not heritable. RNA can be also post-transcriptionally modified. More than 100 modifications have been found and they can occur in transfer RNA, ribosomal RNA, messenger RNA or other non-coding RNAs. Post-transcriptional modifications in RNA are known for more than four decades but their function remains unknown.

My previous work showed that methylation of tRNA at cytosine-5 (m5C) can modulate protein translation and also regulate stress responses in cancer stem cells. My research now focuses on finding novel RNA modifications that confer cell growth and survival advantages to cancer cells.

The seminar will be held in the Lister and Young Seminar Room, 12.30pm - 13.30pm.

If you would like to arrange to talk with Dr Blanco, please contact Esther Castellano Sanchez (e.castellano-sanchez@qmul.ac.uk

Special Seminar - Associate Professor Wenyi Wang from MD Anderson - Thursday 8th February

Thu. 8 Feb, 2018 12:30 pm - 1:30 pm
Thu. 8 Feb, 2018 12:30 pm - 1:30 pm
This event does not repeat

On Thursday 8th February, we are pleased to welcome Associate Professor Wenyi Wang from MD Anderson to present at the BCI.

The seminar is entitled: “Statistical methods for the deconvolution of high-throughput sequencing data from heterogeneous tumor samples”

Abstract: Tumor tissue samples are comprised of a mixture of cancerous and surrounding stromal cells. Understanding tumor heterogeneity is crucial to analyzing gene signatures associated with cancer prognosis and treatment decisions. Compared with the experimental approach of laser capture micro-dissection to isolate different tissue components, in silico dissection of mixed cell samples is faster and cheaper. Numerous computational approaches previously developed all have their limitations to deconvolute heterogeneous tumor samples. In this talk, I will present a new three-component deconvolution model, DeMixT, that can account for the immune cell compartment explicitly and is able to address the challenging problem when the observed signals are assumed to come from a mixture of three cell compartments, infiltrated immune cells, tumor microenvironment and cancerous tissues. I will also talk briefly about DNAseq based deconvolution methods that my lab developed for the analysis of ICGC PCAWG whole-genome sequencing data.

The seminar will be held in the Lister and Young Seminar Room, 12.30 – 13.30pm

If you would like to arrange to speak with Wenyi Wang, please contact Trevor Graham (t.graham@qmul.ac.uk).

Thursday Seminar Series – Professor Jessica Downs from the ICR – Thursday 8th March

Thu. 8 Mar, 2018 12:30 pm - 1:30 pm
Thu. 8 Mar, 2018 12:30 pm - 1:30 pm
This event does not repeat

On Thursday 8th March, we are happy to welcome Professor Jessica Downs from the ICR to present at the BCI. More information about Professor Downs’ research can be found here

The seminar is entitled: ‘Chromatin remodelling, cohesin, and the maintenance of genome stability’

The seminar will be held in the Lister and Young Seminar Room, 12.30pm – 13.30pm.

Furthermore we will be having an informal lunch directly after the seminar for students and post-docs to get to know the speaker, and ask any questions. These lunches can be a great opportunity to get career and informal advice from successful scientists and I really encourage as many of you as possible to stick around. There will be some sandwiches too.

Professor Downs was previously at the Genome Damage and Stability Centre in Sussex for several years. Her work focuses on the role of epigenetics in maintaining genome stability, and she has a very long list of key publications regarding the role of epigenetics and cohesion in DNA damage repair and aneuploidy:

https://www.icr.ac.uk/our-research/researchers-and-teams/professor-jessica-downs/publications#null 

If you would like to arrange to talk with Professor Downs, please contact Sarah McClelland(s.mcclelland@qmul.ac.uk

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Barts Cancer Institute,
Queen Mary University of London,
Charterhouse Square,
London,

EC1M 6BQ

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