Mr Ateequlah Hayat

Analysis of epigenetic alterations during transformation of KRas G12D mutant cells". We use this model system to understand the effect of oncogenic mutations on the epigenetic landscape of cells, which are known to further develop and adapt the cells to the transformed condition. The aim is to use this knowledge to find means to inhibit full transformation of cells that acquired an oncogenic mutation and escaped senescence and programmed cell death.