Dr Daniela Loessner

Dr Daniela Loessner

PhD
Centre: Cancer & Inflammation
Reader in Bioengineering and Cancer
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I am a cell biologist because I wish to make a difference to patients diagnosed with cancer.

Working here at the Barts Cancer Institute allows me to use interdisciplinary approaches to develop 3D models that mimic the human disease in the laboratory and to find better therapeutics.

Research Details

My research interests are to understand the role of the extracellular and cellular microenvironment in modulating cancer progression and therapy response applying tissue-engineered technologies.

I am developing bioengineered 3D platforms that will enable us to:

  • recreate the tumour microenvironment;
  • dissect the complex cellular communications, taking place within tumour spheroids and between tumour spheroids and their extracellular microenvironment;
  • molecularly profile the tumour microenvironment and identify novel targets that can be pursued therapeutically;
  • preclinically screen new therapeutics or combination therapies to inform clinical trials.

Also in my group:

Research Assistant- Shreya Sharma

Profile

I joined the Centre for Cancer and Inflammation in March 2017. Until February 2017, I was leading the interdisciplinary 3D Cancer Models Team at the Centre for Regenerative Medicine, at the Institute of Health and Biomedical Innovation in Brisbane, Australia.

I received my PhD from the Faculty of Chemistry, Technical University of Munich, Germany, and undertook my postdoctoral research training at Queensland University of Technology, EPFL and University of Chicago.

Key Publications

Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms. Loessner D, Meinert C, Kaemmerer E, Martine LC, Yue K, Levett PA, Klein TJ, Melchels FPW, Khademhosseini A, Hutmacher DW. Nature Protocols (2016) 11(4): 727-746. PMID: 26985572

Gelatine methacrylamide-based hydrogels: an alternative 3D cancer cell culture system. Kaemmerer E, Melchels FPW, Holzapfel BM, Meckel T, Hutmacher DW, Loessner D. Acta Biomaterialia (2014) 10(6): 2551-2562. PMID: 24590158

Engineered microenvironments provide new insights into ovarian and prostate cancer progression and drug responses. Loessner D, Holzapfel BM, Clements JA. Advanced Drug Delivery Reviews (2014) 79-80: 193-213. PMID: 24969478

Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of ovarian cancer cells. Loessner D, Stok KS, Lutolf MP, Hutmacher DW, Clements JA, Rizzi SC. Biomaterials (2010) 31(32): 8494-8506. PMID: 20709389


Further Publications

For additional publications, please click here

I am a cell biologist because I wish to make a difference to patients diagnosed with cancer.

Working here at the Barts Cancer Institute allows me to use interdisciplinary approaches to develop 3D models that mimic the human disease in the laboratory and to find better therapeutics.

External Activities

Member of

  • The Tissue Engineering & Regenerative Medicine International Society (TERMIS)
  • The American Association for Cancer Research (AACR)
  • The European Association for Cancer Research (EACR)

News

  • Sept 2018: I am organising and chairing a symposium entitled Recapitulating tumour microenvironments to screen biotherapeutics (session 58) at the 5th TERMIS World Congress, 4-7 Sept 2018, in Kyoto, Japan.
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