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X-ORIGINAL-URL:https://www.bci.qmul.ac.uk
X-WR-CALDESC:Events for Barts Cancer Institute - Queen Mary University of London
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/London:20191105T123000
DTEND;TZID=Europe/London:20191105T133000
DTSTAMP:20260412T015357
CREATED:20191104T113449Z
LAST-MODIFIED:20191104T113449Z
UID:4610-1572957000-1572960600@www.bci.qmul.ac.uk
SUMMARY:Special Seminar - Dr Roberto Bellelli
DESCRIPTION:We are pleased to welcome Dr Roberto Bellelli from The Francis Crick Institute\, to present at CRUK Barts Centre on Tuesday 5th November. \nThe seminar is entitled: ‘Mechanisms of genetic and epigenetic instability: Pol Epsilon and beyond’ \nGenomic instability is a major hallmark of cancer and understanding its nature and origins may provide avenues for patient-tailored therapies. The plasticity of cancer cells is also suggestive of epigenetic mechanisms at the heart of cancer development\, which add a further level of complexity to the challenge of tumour heterogeneity. Indeed\, epigenetic instability\, due to alteration of DNA methylation\, histone post-translational modifications and/or chromatin remodelers has been observed in most malignancies and is now considered a bona fide hallmark of cancer. Despite this\, the interplay between genetic and epigenetic instability remains to be clarified\, particularly in the context of DNA replication\, which represents an opportunity for both genome and epigenome deregulation. \nA paradigm in this area of research is mammalian DNA polymerase Epsilon and its smallest subunits\, POLE3-POLE4\, which I have discovered promotes both efficient replication initiation and facilitates Histone H3-H4 recycling at the replication fork to maintain genetic and epigenetic stability\, respectively.  Through the generation of a mouse knock-out for Pole4 and the identification of POLE1 mutations in patients affected by IMAGe syndrome (Intrauterine growth restriction\, Metaphyseal dysplasia\, Adrenal Hypoplasia and genital anomalies) and immunodeficiency\, I have described the mechanistic consequences of Pol Epsilon instability in genome maintenance\, mammalian development and tumorigenesis. More recently I discovered that POLE3-POLE4 interacts with and chaperones H3-H4 at the replication fork to maintain epigenome integrity and described the molecular determinants of this activity. \nThis work suggests the critical need to dissect in vitro and in vivo the relative contribution of these functions and emphasizes a possible interplay\, yet to be identified\, with histone chaperones\, chromatin remodelers and other replisome components. Identification of these players and their crosstalk in the context of chromatin replication will be of fundamental importance to understand the basis of epigenetic inheritance in mammals and its pathological alteration in cancer. \nThe seminar will be held in the Lister and Young Seminar Room\, 12:30-13:30.
URL:https://www.bci.qmul.ac.uk/event/special-seminar-dr-roberto-bellelli/
LOCATION:Lister and Young Seminar Room\, John Vane Science Centre\, London\, EC1M 6BQ
CATEGORIES:Special Seminars
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BEGIN:VEVENT
DTSTART;TZID=Europe/London:20191107T123000
DTEND;TZID=Europe/London:20191107T133000
DTSTAMP:20260412T015357
CREATED:20191104T104423Z
LAST-MODIFIED:20191104T104423Z
UID:4608-1573129800-1573133400@www.bci.qmul.ac.uk
SUMMARY:Special Seminar – Dr Richard Beatson
DESCRIPTION:As part of the BCI’s Seminar Series\, we are pleased to welcome Dr Richard Beatson from King’s College London to present at the BCI on Thursday 7th November. For more information about Richard Beaton’s work please see below. \nThe seminar is entitled: “Sialic acids as innate immune activators; balancing self and non-self to repair or react” \nThe seminar will be held in the Lister and Young Seminar Room\, 12.30pm – 13.30pm. \nRichard is a Research Fellow at King’s College London. Trained in medicine (Glasgow)\, immunology (UCL) and glycobiology (KCL) Richard has been studying the cross-talk between cancer-associated O-linked glycans and host immune cells for over 10 years. He is currently investigating the ability of MUC1 carrying sialylated O-linked glycans to drive monocytes to differentiate into ‘wound healing’ macrophages\, and assessing the prevalence of these processes in breast cancers. Richard has additional interests in gamma delta T cells (for adoptive cancer therapy)\, chronic inflammatory disease (inflammatory arthritis and idiopathic pulmonary fibrosis) and plant derived immunological tools.
URL:https://www.bci.qmul.ac.uk/event/special-seminar-dr-richard-beatson/
LOCATION:Lister and Young Seminar Room\, John Vane Science Centre\, London\, EC1M 6BQ
CATEGORIES:Special Seminars
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BEGIN:VEVENT
DTSTART;TZID=Europe/London:20191111T100000
DTEND;TZID=Europe/London:20191111T110000
DTSTAMP:20260412T015357
CREATED:20191108T114736Z
LAST-MODIFIED:20191108T114736Z
UID:4626-1573466400-1573470000@www.bci.qmul.ac.uk
SUMMARY:Special Seminar - Dr Rakesh Heer
DESCRIPTION:We are pleased to welcome Dr Rakesh Heer\, Joint CRUK/RCS(Eng) Clinician Scientist Fellow and hon. Consultant Urological Surgeon – Newcastle University\, to present at Barts Cancer Institute on Monday 11th November.  For more information about Dr Heer’s work\, please click here. \nThe seminar is entitled: ‘Human prostate stem cell biology in homeostasis\, ageing and disease’ \nHaving completed undergraduate medical training in Nottingham in 1997\, Rakesh moved to the North East to undertake surgical training and pursue a career in urology. He became interested in prostate biology and went onto to complete a PhD studying stem cell biology in 2006 at Newcastle University. This work led to two prizes: (i) EUA’s Best Urological Paper (2008) and (ii) a Hunterian Professorship from Royal College of Surgeons of England (2010). This work lay the foundations for a CRUK Clinician Scientist Fellowship that led to a seminal description of human prostate homeostasis. Rakesh was appointed senior lecturer in Newcastle in 2011 pursues specialist clinical and research interests in prostate and bladder cancer. In his talk\, Rakesh will present his work on developing stem cell models to study prostate maintenance\, age-related changes and carcinogenesis. \nThe seminar will be held in the Lister and Young Seminar Room\, 10:00-11:00.
URL:https://www.bci.qmul.ac.uk/event/special-seminar-dr-rakesh-heer/
LOCATION:Lister and Young Seminar Room\, John Vane Science Centre\, London\, EC1M 6BQ
CATEGORIES:Special Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/London:20191114T123000
DTEND;TZID=Europe/London:20191114T133000
DTSTAMP:20260412T015357
CREATED:20191111T120355Z
LAST-MODIFIED:20191111T120355Z
UID:4630-1573734600-1573738200@www.bci.qmul.ac.uk
SUMMARY:Thursday Seminar Series - Dr Gabriella Ficz
DESCRIPTION:As part of the BCI’s Seminar Series\, we are pleased to announce that Dr Gabriella Ficz will be presenting on Thursday 14th November. For more information about Dr Ficz’s work please click here. \nThe seminar is entitled: “Making sense of DNA methylation in cancer” \nThe seminar will be held in the Lister and Young Seminar Room\, 12:30-13:30.
URL:https://www.bci.qmul.ac.uk/event/thursday-seminar-series-dr-gabriella-ficz/
LOCATION:Lister and Young Seminar Room\, John Vane Science Centre\, London\, EC1M 6BQ
CATEGORIES:BCI@CHSQ Seminars,Thursday Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=Europe/London:20191121T123000
DTEND;TZID=Europe/London:20191121T133000
DTSTAMP:20260412T015357
CREATED:20191119T120726Z
LAST-MODIFIED:20191119T120726Z
UID:4643-1574339400-1574343000@www.bci.qmul.ac.uk
SUMMARY:Thursday Seminar Series - Dr Benjamin Werner
DESCRIPTION:As part of the BCI’s Seminar Series\, we are pleased to announce that Dr Benjamin Werner will be presenting on Thursday 21st November. For more information about Dr Werner’s work please click here. \nThe seminar is entitled: “Mathematics of Cancer Evolution” \nThe seminar will be held in the Lister and Young Seminar Room\, 12:30-13:30.
URL:https://www.bci.qmul.ac.uk/event/thursday-seminar-series-dr-benjamin-werner-2/
LOCATION:Lister and Young Seminar Room\, John Vane Science Centre\, London\, EC1M 6BQ
CATEGORIES:BCI@CHSQ Seminars,Thursday Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=Europe/London:20191122T090000
DTEND;TZID=Europe/London:20191122T130000
DTSTAMP:20260412T015357
CREATED:20191119T162517Z
LAST-MODIFIED:20191119T162517Z
UID:4649-1574413200-1574427600@www.bci.qmul.ac.uk
SUMMARY:Miltenyi Biotec Exhibition – Friday 22nd November 2019
DESCRIPTION:We are pleased to announce that Miltenyi Biotec will be holding an exhibition on Friday 22nd November 2019. \nMiltenyi Biotec is the leading cell separation company\, offering flexible and reliable solutions for your whole workflow. Come take a look at our End-of-Year offers and prize draws\, and learn more about our recombinantly engineered antibodies for better reproducibility and higher specificity in your flow experiments.  We offer solutions for tissue dissociation\, cell separation\, analysis\, culture – and more. \nThe exhibition will be held in the JVSC foyer from 9:00am – 13:00pm. \nFor more information about the Exhibition\, please click here: Miltenyi Biotec Exhibition Poster
URL:https://www.bci.qmul.ac.uk/event/miltenyi-biotec-exhibition-friday-22nd-november-2019/
LOCATION:John Vane Science Centre Foyer\, Barts Cancer Institute\, Charterhouse Square\, London\, EC1M 6BQ\, United Kingdom
CATEGORIES:BCI@CHSQ Seminars,Exhibitions
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