Centre for Cancer Biomarkers & Biotherapeutics

Our overarching vision within the Centre is to apply our skills and expertise in developing innovative personalised diagnostic, prognostic and therapeutic strategies. Research focuses on the discovery of new biomarkers for earlier diagnosis, monitoring disease progression and response to treatment, and identifying those individuals at risk of disease, and developing targeted treatments.

Centre Description

The Centre for Cancer Biomarkers & Biotherapeutics is located in the Barts Cancer Institute, a CRUK Centre of Excellence dedicated to delivering world-leading research.

We comprise a multidisciplinary team of surgeons, clinicians, pathologists, basic scientists, biobanking professionals and bioinformaticians; working together towards a common goal.

Our overarching vision is to apply our skills and expertise in developing innovative personalised diagnostic, prognostic and therapeutic strategies.

Research focuses on the discovery of new biomarkers for earlier diagnosis, monitoring disease progression and response to treatment, and identifying those individuals at risk of disease, and developing targeted treatments.

Our activities are enhanced by our involvement with local and national biobanks: within the Centre, we have biobanking professionals for specimen management and bioinformaticians for analysing molecular data. Our diversity of research specialities offers an unparalleled opportunity to create a biobanking system in which clinical, molecular and pathologic data are linked.

We are committed to enhancing the teaching experience both for students and the general public through our teaching and outreach activities.

Centre Details

Claude Chelala

Professor Claude Chelala

Deputy Centre Lead

Centre Address:

John Vane Science Centre,
Charterhouse Square,
London EC1M 6BQ

Research groups


Claude Chelala

Professor Claude Chelala

Professor of Bioinformatics

Professor Tatjana Crnogorac-Jurcevic

Professor of Molecular Pathology and Biomarkers

Professor Nick Lemoine

Professor of Molecular Oncology

Professor Yong-Jie Lu

Professor of Molecular Oncology

Dr Oscar Maiques

Lecturer in Digital Pathology

Dr Vivek Singh

Lecturer in Digital Pathology

Professor Jane Sosabowski

Professor of Radionuclide Imaging and Therapy

Professor Peter Szlosarek

Professor of Medical Oncology

Yaohe Wang profile picture

Professor Yaohe Wang

Professor of Cancer Cell and Gene Therapy

Fluorescently stained cells against a black background, with pink signals marking specific regions inside cloudy white nuclei.

DNA-copying overload may reveal which cancer cells respond to ATR-inhibitor drugs

Researchers have uncovered a mechanism that makes some cancer cells especially vulnerable to experimental drugs known as ATR inhibitors. The findings could support the development of tests to identify the patients most likely to benefit.

Publications   17 August 2026

Artwork by Niten Patel Design. Illustration shows a woman and man against a background combining elements of the UK, Bangladesh and Pakistan flags, with a DNA helix between them.

Study reveals gaps in cancer risk assessment and genetic tools for British Bangladeshi and Pakistani communities

Scientists have carried out one of the largest and most comprehensive studies to date of the genetic and clinical factors associated with cancer in British Bangladeshi and Pakistani people. The findings could help inform future efforts to make cancer screening and risk assessment more equitable.

Publications   7 August 2026

New spinout launches to advance early pancreatic cancer detection

Queen Mary University of London has launched a new company, Procyon Diagnostics, to provide pioneering early cancer detection tests. The company’s first test, PancRISK, offers new hope for detecting pancreatic cancer earlier, building on over 15 years of research by Professor Tatjana Crnogorac-Jurcevic at Queen Mary’s Barts Cancer Institute (BCI), funded by the Pancreatic Cancer Research Fund.

General News   29 October 2025

Key Publications

  • The clinical and molecular landscape of breast cancer in women of African and South Asian ancestry. Nat Commun (2025). 16(1):4237. PMID: 40394000
  • Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis. Nat Commun (2025). 16(1):1394. PMID: 39952917
  • Overcoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma. iScience (2024). 28(1):111525. PMID: 39758821
  • Pegargiminase Plus First-Line Chemotherapy in Patients With Nonepithelioid Pleural Mesothelioma: The ATOMIC-Meso Randomized Clinical Trial. JAMA Oncol (2024). 10(4):475-483. PMID: 38358753
  • S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer. Oncogene (2023). 42(46):3422-3434. PMID: 37794133
  • Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer’. BMC Cancer (2022) 22:369. PMID: 35392854
  • Fulvestrant Plus Vistusertib vs Fulvestrant Plus Everolimus vs Fulvestrant Alone for Women With Hormone Receptor-Positive Metastatic Breast Cancer: The MANTA Phase 2 Randomized Clinical Trial. JAMA Oncol (2019). PMID: 31465093