Centre for Cancer Cell & Molecular Biology

Our main mission within the Centre is to elucidate the fundamental mechanisms of cancer cell biology and how these can be therapeutically targeted. Our central aim is to understand the basic biology of cancer cells and harness this knowledge to identify new treatment strategies.

Centre Description

Welcome to the Centre for Cancer Cell and Molecular Biology, where our main mission is to elucidate the fundamental mechanisms of cancer cell biology and how these can be therapeutically targeted.

We are a centre of excellence in state-of-the-art research and clinical translation, which brings together internationally-recognised basic science and clinical academics.

Our central aim is to understand the basic biology of cancer cells and harness this knowledge to identify new treatment strategies.

Our Centre is embedded in one of the UK’s top medical schools thus offering excellent opportunities for multidisciplinary collaborations.

Centre Details

Centre Address:

Ground Floor, John Vane Science Centre,
Charterhouse Square,
London EC1M 6BQ

Research groups


Dr Roberto Bellelli

Senior Lecturer

Dr Katiuscia Bianchi

Reader in Cell Biology

Dr Gabriella Ficz

Reader in Molecular Biology and Epigenetics

Professor Susana Godinho

Professor in Cancer Cell Biology

Tommy Kaplan profile picture

Professor Tommy Kaplan

Professor of Computational Biology

Dr Pedro Monteiro

Senior Lecturer

Prabhakar Rajan profile picture

Professor Prabhakar Rajan

Professor Urology and Robotic Surgery

Amit Roshan Porfile picture

Dr Amit Roshan

Clinical Senior Lecturer

Professor Tyson V. Sharp

Professor of Cellular and Molecular Biology

Dr Lovorka Stojic

Senior Lecturer

Hui Zhao

Dr Hui Zhao

Lecturer

A stylised 3D illustration of a purple RNA strand curving across a blurred purple and blue molecular background.

Protein lost in lung cancer reveals hidden layer of gene control

Scientists at Barts Cancer Institute, Queen Mary University of London, have uncovered an important way that cells keep their genes under control. The discovery could help explain one of the earliest molecular changes that occurs during the development of lung cancer. The study, published in Science Advances, reveals that a protein called LIMD1, which is frequently lost in lung cancer, plays a much bigger role in controlling gene activity than scientists previously realised. The findings uncover a previously hidden layer of gene regulation and may provide new insight into how normal cells begin to lose control during the earliest stages of cancer.

Publications   23 July 2026

Gloved hand holding a blood sample in a purple-capped tube with racks of test tubes in a clinical lab setting.

AI combines multiple DNA clues to improve cancer detection from blood

Researchers have developed an artificial intelligence method that can detect signs of cancer by combining several different clues found in DNA fragments circulating in the blood. The method, developed by a team led by scientists at Barts Cancer Institute, Queen Mary University of London, and the University of Cambridge, uses a comparatively inexpensive form of genome sequencing to detect signals shared by a range of cancer types.

Publications   10 July 2026

Scientists awarded £5.7m to harness epigenetics in next-generation anti-viral therapies

BCI researcher Dr Gabriella Ficz and team have been awarded funding as part of a £5.7m national collaborative initiative exploring how epigenetics can be harnessed to strengthen our immune system’s ability to fight viruses. Dr Ficz will receive £880,000 to support her team’s contribution to the epiPRIME project, awarded by the Advanced Research and Invention Agency (ARIA).

Grants & Awards   25 June 2026

Key Publications

  • The genetic and biochemical basis of human leading strand synthesis. Nat Commun (2025). 17(1):412. PMID: 41339636
  • Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors. Cell Rep (2024). 43(5):114205. PMID: 38753485
  • CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny. Proc Natl Acad Sci U S A (2023). 120(34):e2300224120. PMID: 37579157
  • Centrosome amplification fine tunes tubulin acetylation to differentially control intracellular organization. EMBO J (2023). 42(16):e112812. PMID: 37403793
  • Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes. Cell Death Dis (2021) 12, 1075. PMID: 34764236
  • Subcellular mRNA localization regulates ribosome biogenesis in migrating cells. Dev Cell (2020) 55(3):298-313.e10. PMID: 33171110
  • A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Nat Commun (2020) 11(1):1851. PMID: 32296040
  • MLH1 deficiency leads to deregulated mitochondrial metabolism. Cell Death & Disease (2019) 10(11):795. PMID: 31641109
  • Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Dev Cell (2018) 47(4):409-424. PMID: 30458137
  • A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. EMBO Mol Med (2018) PMID: 29930174