Centre for Haemato-Oncology

This Centre seeks to understand the molecular basis for lymphoma, leukaemia and myeloma to identify targets for novel targeted therapies and to identify biomarkers of prognosis and response to treatment. We also seek to understand the impact of the tumour microenvironment on malignant cell survival and resistance to therapy. A long-standing strength has been the translational components with strong links to the clinic through clinical senior lecturers and clinical research fellowships and high enrolment of patients in clinical trials.

Centre Description

Welcome to the Centre for Haemato-Oncology, where our main mission is to find cures for haematologic malignancies. We are a centre of excellence in state-of-the-art research and clinical translation, which brings together internationally-recognised basic scientists with top clinical academics.

Our central aim is to understand the biology of leukaemias and lymphomas and harness this knowledge to identify new treatment strategies. Working closely together with the Haemato-oncology department at the St Bartholomew’s Hospital Cancer Centre we are uniquely well placed to implement our findings in clinical practice. Moreover, our Centre is embedded in Queen Mary’s Faculty of Medicine and Dentistry, one of the UK’s top medical schools, thus offering excellent opportunities for multidisciplinary collaborations.

Our main research themes and their associated faculty include:

  1. Stem cell biology and normal haematopoiesis (Laboratories: Ganuza, NguyenRouault-Pierre)
  2. Biology and therapeutic targeting of leukaemia (Laboratories: GribbenGallipoli, NguyenRiches, Rouault-PierreWrench)
  3. Pathogenesis and treatment of lymphomas (Laboratories: BraunOkosun, Riches)
  4. Improving immunotherapy in blood malignancies (Laboratories: Davies, GribbenLe Dieu)

Centre Details

Professor Jessica Okosun

Deputy Centre Lead

Centre Address:

John Vane Science Centre,
Charterhouse Square,
London EC1M 6BQ

Research groups


Professor Andrejs Braun

Professor of Genome Regulation

Jeff Davies profile picture

Dr Jeff Davies

Reader in Haemato-oncology and Honorary Consultant

Dr Özgen Deniz

Senior Lecturer

Dr Rifca Le Dieu

Clinical Reader

Dr Paolo Gallipoli

Clinical Reader in Experimental Haematology

Dr Miguel Ganuza

Reader in Haematopoietic Stem Cell Biology

Professor John Gribben

Professor of Medical Oncology

A person wearing tortoiseshell glasses in a laboratory, with shelves of lab supplies and equipment in the background.

Dr Diu T. T. Nguyen

Senior Lecturer

Professor Jessica Okosun

Professor of Translational Cancer Research

Dr John Riches

Clinical Reader in Cancer Immuno-metabolism

Dr Kevin Rouault-Pierre

Reader in Stem Cell Biology and Disease

Dr Bela Wrench

Clinical Senior Lecturer

Red blood cells

New £1m clinical trial launches to improve quality of life for people with myelodysplastic syndromes

Researchers have been awarded £1m to launch a new clinical trial for people with myelodysplastic syndromes, a form of blood cancer with limited treatment options.

Publications   8 April 2026

Could a breath test detect blood cancer?

Molecules exhaled in the breath may provide clues to detect blood cancer, according to new research by scientists at Barts Cancer Institute. The findings could enable the development of a blood cancer breathalyser, providing a rapid, low-cost way to detect disease.

General News   23 July 2025

Cells’ recycling system plays a surprising role in shaping immune cells DNA

Researchers have discovered a new mechanism by which B cells – antibody-producing immune cells – use a cellular recycling process called autophagy to control changes to their DNA essential for antibody improvement. The findings could have future implications for the development of certain blood cancers and autoimmune diseases.

General News   2 July 2025

Key Publications

  • Analysis of volatile organic compounds in exhaled breath of blood cancer patients identifies products of lipid peroxidation as biomarkers for lymphoma detection. HemaSphere (2025). 9(7):e70168. PMID: 40687178
  • Autophagy is an upstream mediator of chromatin dynamics in normal and autoimmune germinal center B cells. J Clin Invest (2025). 135(13):e178920. PMID: 40397664
  • Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation. Leukemia (2024). 38(11):2395-2409. PMID: 39187579
  • Pivotal role of the endoplasmic reticulum stress-related XBP1s/miR-22/SIRT1 axis in acute myeloid leukemia apoptosis and response to chemotherapy. Leukemia (2024). 38(8):1764-1776. PMID: 38909090
  • Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nat Commun (2023). 14(1):2132. PMID: 37059720