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Professor Francesca Ciccarelli
Professor of Cancer Genomics, Barts Cancer Institute Principal Group Leader, Cancer Systems Biology, The Francis Crick Institute

Our group investigates cancer evolution, with a focus on understanding how genetic changes influence disease progression, response to therapy and development of resistance. We particularly concentrate on gastrointestinal cancers such as colorectal, stomach and oesophageal cancer.

Dr Mirjana Efremova
Senior Lecturer

We are interested in understanding the cellular and molecular mechanisms that promote cancer cell plasticity and adaptation of tumour cells in metastatic niches and under therapeutic pressure.

Professor Marco Gerlinger
Professor of Gastrointestinal Cancer Medicine; Consultant Medical Oncologist and Director of GI Cancer Research at St. Bartholomew's Hospital

We are investigating how drug resistance evolves in bowel and gastro-oesophageal cancers, how these tumour types can be treated more effectively through novel immunotherapies and targeted drugs, and how treatment sensitivity and resistance can be predicted.

Professor Stuart McDonald
Professor of Gastrointestinal Biology

Our main research areas are focused on understanding the evolution of Barrett’s oesophagus to cancer, field cancerisation of the human stomach, and clonal expansion in ductal carcinoma in situ of the human breast.

Dr Vivek Singh
Lecturer in Digital Pathology
Professor Sir Nicholas Wright
Emeritus Professor of Histopathology

My research interests include clonal evolution in colorectal adenomas and inflammation-associated cancer, the nature of Barrett’s glands, and the design of methods to explore neutral drift in stem cell divisions in normal human tissues.

Dr Lucas Baumard

In my research, I examine the response of immune cells to different chemotherapy drugs in order to develop more effective cancer immunotherapy combinations. I use patient-derived organoids (from oesophageal cancer patients), 3D models, T cell co-culture models, flow cytometry, IHC(-F, H&E) and ELISA.

Dr Marta Buzzetti

My research focuses on the use of patient-derived organoid co-cultures and genome wide CRISPR screens to unravel tumour intrinsic gene networks controlling resistance to CD3 bispecific antibodies in colorectal cancer, and possibly applicable to other tumour types.

Dr Alice Coomer

My research aims to understand the mechanisms through which long noncoding RNAs can control genome stability in cancer.

Dr Giulia Guiducci

My research activity aims to characterise lncRNAs involved in the maintenance of genomic stability and to understand how their dysregulation can lead to cancer development.

Dr Florian Laforets

My research in Prof Balkwill’s group focuses on imaging tumour-associated macrophages and other immune cells in live ex vivo tumour slices, in order to assess their behaviour and the impact of immunotherapies on the live tumour microenvironment.

Dr Sam Ogden

We are using single cell multi-omic approaches to study how cancer cell plasticity and the tumour microenvironment contribute to metastasis in colorectal cancer.

Dr Emma Taggart

My research aims to investigate the immune microenvironment in colorectal cancer, and particularly how it influences response to immunotherapy. To explore this, I am developing co-culture models using patient-derived colorectal cancer tissue and primary human immune cells including T cells and macrophages.

Dr Mingyu Ye

My research focuses on Vaccinia virus (VACV) as a candidate for oncolytic virotherapy, an extremely effective strategy that can simultaneously target multiple features of the suppressive tumour microenvironment (TME) in cancer and sensitize the tumours to other forms of immune or traditional therapeutics.