Dr Daniela Loessner

Dr Daniela Loessner

PhD
Centre: Cancer & Inflammation
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I am a cell biologist because I wish to make a difference to patients diagnosed with cancer.

Working here at the Barts Cancer Institute allows me to use interdisciplinary approaches to develop 3D models that mimic the human disease in the laboratory and to find better therapeutics.

Research Details

My research is placed at the interface between Cancer Cell Biology and Tissue Engineering, with the aim to develop bioengineered 3D co-culture models that recreate the tumour microenvironment.

These bioengineered platforms will enable us to:

- dissect the complex cellular communications, taking place within multi-cellular cancer spheroids and between cancer spheroids and their niche

- screen new therapeutics that specifically target the tumour microenvironment.

Profile

I joined the Centre for Cancer and Inflammation in March 2017. Until February 2017, I was leading the interdisciplinary 3D Cancer Models Team at the Centre for Regenerative Medicine, at the Institute of Health and Biomedical Innovation in Brisbane, Australia.

I received my PhD from the Faculty of Chemistry, Technical University of Munich, Germany, and undertook my postdoctoral research training at Queensland University of Technology, EPFL and University of Chicago.

Key Publications

Tourell MC, Shokoohmand A, Landgraf M, Holzapfel NP, Poh PSP, Loessner D#, Momot KI#. The distribution of the apparent diffusion coefficient as an indicator of the response to chemotherapeutics in ovarian tumour xenografts. Scientific Reports 7: 42905, 2017. #shared senior authors. PMID: 28220831

Loessner D, Meinert C, Kaemmerer E, Martine LC, Yue K, Levett PA, Klein TJ, Melchels FPW, Khademhosseini A, Hutmacher DW. Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms. Nature Protocols 11(4): 727-746, 2016. PMID: 26985572

Kaemmerer E, Melchels FPW, Holzapfel BM, Meckel T, Hutmacher DW, Loessner D. Gelatine methacrylamide-based hydrogels: an alternative 3D cancer cell culture system. Acta Biomaterialia 10(6): 2551-2562, 2014. PMID: 24590158

Loessner D, Stok KS, Lutolf MP, Hutmacher DW, Clements JA, Rizzi SC. Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of ovarian cancer cells. Biomaterials 31(32): 8494-8506, 2010. PMID: 20709389


 Further Publications

For additional publications, please click here

I am a cell biologist because I wish to make a difference to patients diagnosed with cancer.

Working here at the Barts Cancer Institute allows me to use interdisciplinary approaches to develop 3D models that mimic the human disease in the laboratory and to find better therapeutics.

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