Dr Faraz Mardakheh

Dr Faraz Mardakheh

BSc, PhD
Centre: Centre for Molecular Oncology
Lecturer
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My lab studies how synthesis of cellular proteins is spatially and temporally dysregulated in cancer cells, and how this dysregulation contributes to cancer progression.

Research Details

Each cell in our body contains the same genetic information, yet this information is read out in diverse ways, allowing different cell types to acquire distinct characteristics.

Importantly, the decoding of genetic information can be corrupted in diseases such as cancer, resulting in undesired characteristics, such as unrestricted proliferation and invasion of malignant cells into other tissues and organs.

The decoding of genetic information occurs sequentially from DNA, via messenger-RNA (mRNA), to proteins, the final and functional products of most genes. My lab is interested in understanding how synthesis of cellular proteins from mRNA is dysregulated during cancer progression.

Using cutting-edge quantitative proteomics, RNA-seq, and bioinformatics methodologies, along with a variety of cell based and biochemical assays, we study how protein translation is controlled in time and space, and how this regulation is altered during cancer progression.
Currently, the lab is focused on three main projects:

  1. The role of localised protein translation in controlling cancer cell migration, invasion, and metastasis.
  1. The role of mRNA localisation in post-transcriptional regulation of gene expression, in normal and malignant cells.
  1. How oncogenes trigger malignancy by dysregulating gene expression at the level of protein translation.

Ultimately, our goal is to understand how various aspects of cancer progression is mediated by spatial and temporal dysregulation of protein synthesis, in hope of revealing novel therapeutic targets that can be exploited to tackle malignancy.

Current members of the lab:

Dr Maria Dermit Salazar (postdoctoral research assistant)

Mr Martin Dodel (research technician)

Mr Muhammad Syahmi Bin Azman (Barry Reed PhD student)

Mr Elliott Whittaker (Intern)

 

 

 

 

Profile

2017: Group leader at Barts Cancer Institute, Queen Mary University of London, London, UK.

2010-2016: Postdoctoral Research Fellow – Professor Christopher J. Marshall’s laboratory, Institute of Cancer Research, London, UK. (Regulation of polarity during cell migration via RNA localisation and local translation)

2006-2010: PhD in Biology – Professor John K. Heath’s laboratory, University of Birmingham, Birmingham, UK. (Feedback regulation of Receptor Tyrosine Kinase signalling by Sprouty and Spred)

2004-2006: BSc with Honours Class I in Biochemistry – University of Birmingham, Birmingham, UK.

Funding

  • 2017-2022 - Medical Research Council Career Development Award - £1,218,815.00
  • 2017-2022 - Barts Charity Grant - £370,603.63 (joint application with Dr Pedro Cutillas)

Key Publications

Global Analysis of mRNA, Translation, and Protein Localization: Local Translation Is a Key Regulator of Cell Protrusions. Mardakheh FK, Paul A, Kümper S, Sadok A, Paterson H, Mccarthy A, Yuan Y, Marshall CJ. Dev Cell. 35(3):344-5, 2015 PMID: 26555054

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis. Kümper S, Mardakheh FK, McCarthy A, Yeo M, Stamp GW, Paul A, Worboys J, Sadok A, Jørgensen C, Guichard S, Marshall CJ.Elife. 5:e12994, 2016 PMID: 26765561

Proteomics profiling of interactome dynamics by colocalisation analysis (COLA). Mardakheh FK, Sailem HZ, Kümper S, Tape CJ, McCully RR, Paul A, Anjomani-Virmouni S, Jørgensen C, Poulogiannis G, Marshall CJ, Bakal C. Mol Biosyst. 13(1):92-105, 2016 PMID: 27824369

RHO binding to FAM65A regulates Golgi reorientation during cell migration. Mardakheh FK, Self A, Marshall CJ. J Cell Sci. 129(24):4466-79, 2016 PMID: 27807006


Further Publications

For additional publications, please click here

 

27807006

My lab studies how synthesis of cellular proteins is spatially and temporally dysregulated in cancer cells, and how this dysregulation contributes to cancer progression.

External Activities

Member of:

  • British Society of Cell Biology (BSCB)
  • Biochemical Society

News

We are currently looking for a postdoctoral fellow and a technician to join the lab. Please e-mail me if you are interested to know more about these positions.

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