Dr Sergey Krysov

Dr Sergey Krysov

PhD
Centre: Centre for Haemato-Oncology
Senior Lecturer
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QMUL Directory


My studies concentrate on the immunogenetics of human B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL).

Research Details

My primary interest is in the role of B-cell receptor (BCR) in the development of B-cell malignancies. The immunoglobulin (Ig) – the largest component of BCR – is a key molecule for B-cells. Individually constructed during antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes, this receptor is "designed" to recognise a specific antigen. The status of the Ig genes allows us to reveal a clonal history of a B-cell tracking down a cell of origin.

The BCR signalling, a part of the support received by the CLL microenvironment, provides favourable conditions for CLL cells' survival and eventually, disease progression. Therefore, the dissection of the BCR signalling provides us clues to possible targets for therapeutic attack and can help developing new approaches to the treatment of the B-cell malignancies.

Currently, I am leading on a number of research projects looking into the development of B-cell malignancies and the role of the B-cell receptor in B-cell lymphoma and leukemia.

Profile

I studied biology at the Tomsk State University (MSc Biology, 1996, Tomsk, Russia). I then completed my PhD project at the Institute of Clinical Immunology (PhD, 2001, Novosibirsk, Russia). In 2002 I joined the Tenovus Research Laboratory at the University of Southampton. In 2007 I transferred, within Southampton, and joined the Chronic lymphocytic leukemia project at Cancer Research Clinical Centre. In May 2014 I was appointed Lecturer at Barts Cancer Institute, QMUL.

ResearchGate

Funding

HEFCE

2017: Leuka, John Goldman Fellowship for Future Science - "A novel B-cell receptor - nuclear repressor ZEB2 axis that defines the clinical outcome in chronic lymphocytic leukaemia." £100,000

2016: Barts Charity, Strategic Research Grant - "Composition of the peripheral blood of CLL patients. Interactions, activation and signaling capacity of B and T-cells." £77,487

2015: Pathological Society of Great Britain and Ireland, PhD Studentship - "High-mannoses in V-region of follicular lymphoma immunoglobulin and their role in lymphoma initiation." £68,000

Key Publications

Linley A, Krysov S, Ponzoni M, Johnson PW, Packham G, Stevenson FK. Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells. Blood. 2015;126(16):1902-10. PMID: 26194765

Coelho V, Krysov S, Steele A, Sanchez Hidalgo M, Johnson PW, Chana PS, Packham G, Stevenson FK, Forconi F. Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function. Blood. 2013;122(15):2664-72. PMID: 23954894

Krysov S, Dias S, Paterson A, Mockridge CI, Potter KN, Smith KA, Ashton-Key M, Stevenson FK, Packham G. Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells. Blood. 2012;119(1):170-9. PMID: 22086413

Krysov S, Potter K, Mockridge CI, Coelho V, Packham G, Stevenson FK. Surface IgM of chronic lymphocytic leukaemia cells displays unusual glycans indicative of engagement of antigen in vivo. Blood 2010;115(21):4198-205. PMID: 20237321


Further Publications

For additional publications, please click here


My studies concentrate on the immunogenetics of human B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL).

External Activities

  • Member of the European Research Initiative on CLL (ERIC)

News

  • UK CLL Forum Hamblin Prize awarded for the best research in CLL, 2011

See other researchers working on:

Blood cancers Cell Signalling Leukaemia Lymphoma
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