Overview
My research aims to define the immune landscape and identify immune determinants that predict progression from actinic keratosis, a common precancerous lesion, to invasive and metastatic cutaneous squamous cell carcinoma (cSCC). I apply single cell RNA-seq, spatial transcriptomics and machine learning approaches to dissect cellular heterogeneity and uncover diagnostic and prognostic markers that stratify high-risk patients. Identifying these markers is critical for early detection, risk assessment, and timely intervention, with the ultimate goal of improving outcomes for patients with aggressive and metastatic disease.