Group Leader: Professor Sarah McClelland
Overview
I work on mechanisms driving Chromosomal Instability (CIN), the DNA damage response to CIN and how that drives aneuploidy, cancer evolution and promotes resistance to chemo and radiotherapy.
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Driving Discoveries for Tomorrow’s Cancer Care
Today, on World Cancer Day, we’re sharing a new film. Join us as we go behind the scenes at Barts Cancer Institute (BCI), Queen Mary University of London and meet the people who are making progress possible.
Video 4 February 2026
Chromosomal instability in ovarian cancer
We spoke with Dr Sarah McClelland and senior postdoctoral researcher in her group, Dr Nadeem Shaikh, about the team’s most recent paper, published in Cancer Research, which set out to explore the mechanisms of chromosomal instability in high-grade serous ovarian carcinoma - the most common type of ovarian cancer. The study sheds light on how these mechanisms may be able to be targeted to overcome treatment resistance in this cancer type.
General News 26 November 2020