Overview
My work has focussed on using naturally-occurring somatic mutations in human cells as lineage markers, extending this to building large somatic phylogenies of hundreds of single haematopoietic stem cells. I have used this approach to study foetal development, ageing of normal blood, allogeneic transplant, gene therapy as well as the fundamental mechanisms of mutagenesis. My interests are to better understand somatic evolution in blood, and its impact on the phenotypes of ageing and disease.