Cancer immunotherapy has revolutionised treatment, but for most patients with solid tumours, it still fails. My team is developing a new class of precision therapies that remodel the tumour extracellular matrix (ECM) to convert immune-excluded tumours into therapy-responsive ones. These ECM-editing interventions are based on our discoveries that specific ECM components, and their post-translational glycosylations (PTGs), control immune cell positioning and function within tumours. By precisely modifying ECM structure our therapies aim to overcome immune exclusion and sensitise tumours to immune-mediated destruction, offering new hope for cancers resistant to current immunotherapy.

To achieve our goals we need to close a major gap by creating in vitro models that enable tumour ECM research; and in this PhD you will develop an in vitro ECM platform used for testing the immune function of ECM targets. This multidisciplinary PhD will involve aspects of materials science, immunology, and matrix biology. Techniques planned include, creation of a 3D tumour on a CHIP, spatial and bulk omics methodologies, gene editing, and real-time cell function and phenotype assays.

Academic Entry Requirements

All applicants should have or be expecting:

• A first or upper second class honours degree in a relevant biological subject from a UK university or the international equivalent from a recognised institution. For international equivalencies please see Queen Mary International Office. Or;
• A medical degree from a recognised institution.

English Language Requirements

Applicants for whom English is not a first language will also require a minimum IELTS score of 6.5 (with 6.0 in the written component) or equivalent, unless your undergraduate degree was studied in, and awarded by, an English speaking country. For more information on acceptable English language qualifications please see here.

Fee Status

The funding for this studentship only covers tuition fees at the Home rate. Overseas applicants are welcome to apply, but will be required to fund the difference in tuition fees.

The studentship includes the following funding for 4 years:

• A tax-free annual stipend of £23,000
• Tuition fees at the Home rate*
• Project consumables

*If you are considered an Overseas student for fee purposes, you are welcome to apply for this studentship, however, you will be required to cover the difference in tuition fees.

To apply you will need to complete an online application form. Please select the non-clinical PhD programme option.

The following supporting documents will be required as part of your application:

• Your CV
• Personal statement
• Details of 2 referees
• Copy of your transcript(s), including a breakdown of marks
• Copy of your passport
• If applicable, proof of English proficiency

If you have a question about the project, or would like to arrange an informal discussion, please contact the supervisor directly (subject ‘PhD applicant’). For general enquiries about the PhD studentship or application process please contact bci-pgresearch@qmul.ac.uk.

Successfully shortlisted candidates will be invited to an interview at Barts Cancer Institute.