Cancer Type: Acute Myeloid Leukaemia

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Dr Mike Williams

8th August 2024

My research focusses on understanding cancer-specific metabolism in acute myeloid leukaemia and targeting this metabolism to overcome therapeutic resistance. I also explore the role of diet and obesity in leukaemogenesis and response to therapy.

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Dr Megha Meena

7th August 2024

We use novel mass cytometry technology following allogeneic haematopoietic stem-cell transplantation in patients, to define the global landscape of immune-cell populations preceding development of acute graft-versus-host disease (aGvHD) and to identify a dominant immunoregulatory role for subsets of CD56hi NK cells in limiting alloreative T-cell expansion and aGvHD.

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Dr Sandra M. Martin-Guerrero

7th August 2024

My work is focused on exploiting cell cycle vulnerabilities in tumour cells, particularly the role of MASTL or Greatwall kinase in cell cycle control. My research will explore the role of MASTL in AML and whether it could be a new therapeutic target in this disease.

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Dr Arantxa Carrasco Leon

7th August 2024

My research project aims to identify germline mutations in acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) and to understand their contribution in the development of these haematological diseases, using in vitro and ex vivo models. This study will lead to a step forward in the diagnosis and treatment of this group of life-threatening diseases.

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Dr James Boncan

26th January 2023

My research investigates the functional relevance of RNA-binding proteins (RBPS) in normal haematopoiesis and acute myeloid leukaemia (AML) pathogenesis.

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