Cancer Type: Colorectal
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Dr Mingyu Ye
8th August 2024
My research focuses on Vaccinia virus (VACV) as a candidate for oncolytic virotherapy, an extremely effective strategy that can simultaneously target multiple features of the suppressive tumour microenvironment (TME) in cancer and sensitize the tumours to other forms of immune or traditional therapeutics.
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Dr Emma Taggart
8th August 2024
My research aims to investigate the immune microenvironment in colorectal cancer, and particularly how it influences response to immunotherapy. To explore this, I am developing co-culture models using patient-derived colorectal cancer tissue and primary human immune cells including T cells and macrophages.
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Dr Lucas Baumard
7th August 2024
In my research, I examine the response of immune cells to different chemotherapy drugs in order to develop more effective cancer immunotherapy combinations. I use patient-derived organoids (from oesophageal cancer patients), 3D models, T cell co-culture models, flow cytometry, IHC(-F, H&E) and ELISA.
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Professor Francesca Ciccarelli
27th October 2023
Our group investigates cancer evolution, with a focus on understanding how genetic changes influence disease progression, response to therapy and development of resistance. We particularly concentrate on gastrointestinal cancers such as colorectal, stomach and oesophageal cancer.
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Dr Marta Buzzetti
11th October 2022
My research focuses on the use of patient-derived organoid co-cultures and genome wide CRISPR screens to unravel tumour intrinsic gene networks controlling resistance to CD3 bispecific antibodies in colorectal cancer, and possibly applicable to other tumour types.
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