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Germinal centre-like structures in the salivary glands of a patient with Sjögren’s syndrome. This microscopy image shows the relationship between molecules involved in the cell’s recycling process (autophagy; shown in red) and Lamin B1 (in green), a protein found at the edge of the cell nucleus. Areas with increased autophagy activity correspond to regions with lower amounts of Lamin B1, suggesting this recycling process helps control Lamin B1 levels in immune cells during autoimmune disease.
Cells’ recycling system plays a surprising role in shaping immune cells DNA

2nd July 2025

Researchers have discovered a new mechanism by which B cells – antibody-producing immune cells – use a cellular recycling process called autophagy to control changes to their DNA essential for antibody improvement. The findings could have future implications for the development of certain blood cancers and autoimmune diseases.

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Study reveals molecules enabling bowel cancer to hijack healing processes and spread

8th June 2025

Scientists have uncovered how bowel cancer cells imitate our gut’s natural healing processes to adapt, spread and grow. The findings researchers at Barts Cancer Institute could lead to new treatment strategies aimed at preventing cancer spread.

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Pancreatic cancer cells grown in culture, SEM. Anne Weston, Francis Crick Institute. Source: Wellcome Collection.
Scientists explore new way to bring CAR-T cell therapy to pancreatic cancer

22nd May 2025

A new strategy to help powerful cancer-targeting immune cells, known as CAR-T cells, infiltrate pancreatic tumours has been developed by researchers at Barts Cancer Institute, Queen Mary University of London. The unique three-pronged approach could pave the way for making CAR-T cell therapy—a treatment that has transformed care for certain blood cancers—effective against pancreatic cancer, a disease that remains very difficult to treat.

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Breast Cancer Inequalities: image shows two women in traditional South Asian and African dresses, with a pink breast cancer awareness ribbon
Beyond ‘one size fits all’: Study reveals ethnic differences in breast cancer development and outcomes, demanding tailored care approaches

20th May 2025

Women of African or South Asian genetic ancestry tend to develop breast cancer and die at a younger age than women of European ancestry, according to new research by Barts Cancer Institute, Queen Mary University of London. The study, which looked at clinical and genetic data from over 7,000 women with breast cancer, also found important genetic differences in these women’s cancers that could impact their diagnosis and treatment.

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Illustration of a blue cancer cell
Smarter chemotherapy approach could delay drug resistance in ovarian cancer

30th April 2025

Adaptive chemotherapy can prolong survival in lab models of ovarian cancer, according to new results. The findings could pave the way for a more effective and gentler approach to treating ovarian cancer that uses existing drugs in a more intelligent way.

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Introducing: Dr Alastair Lamb

3rd April 2025

Welcome to our newest group leader, Dr Alastair Lamb.

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