Staff Centre: Centre for Cancer Cell and Molecular Biology
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Dr Pedro Monteiro
14th May 2025
My research focuses on elucidating the mechanisms underlying cancer cell invasion. In particular, I’m interested in the role of plasma membrane dynamics in mediating cancer cell interaction with its immediate environment, notably by allowing cancer cells to remodel and cleave the extracellular matrix, thus leading to cell breakage into the surrounding environment.
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Dr Lauryn Buckley-Benbow
5th September 2024
My research investigates the mechanisms of sensitisation to PARP and ATR inhibitors and how dysfunction of normal DNA replication leads to genome instability and cancer.
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Dr Jonathan Burden
7th August 2024
My research investigates how centrosome amplification in breast cancer impacts angiogenesis and the tumour microenvironment, and how this can be targeted as a potential cancer therapy.
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Dr Kirsty Brooksbank
7th August 2024
My research is focussed on trying to understand the connection between DNA damage repair deficiency and response to immune checkpoint inhibitors (ICIs). We have a particular focus on investigating the variable response rates to ICIs observed in DNA mismatch repair deficient cancers.
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Dr Alessandro Agnarelli
26th October 2023
My research focuses on investigating the roles of DNA Polymerase Epsilon (Pol ε) in nucleosome assembly. Using a range of biochemical and biophysical techniques (including LC-MS, Cryo-EM), my aim is to elucidate the structural analysis of the interaction between DNA Pol ε and parental histones H3-H4 at replication fork.
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Dr Sam Wallis
10th October 2022
My research uses microscopy to examine how microtubule post-translational modifications affect DNA damage repair and how this could be exploited to enhance chemotherapy.
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