Staff Centre: Centre for Cancer Evolution
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Dr Max Beesley
10th April 2025
My research focuses on improving our understanding of why only certain prostate cancer clones within a patient (intratumoural) undergo metastasis. I will apply next-generation spatial transcriptomics to investigate clonal evolution, identify key driver mutations and better understand clonal interaction with the stromal tumour microenvironment (TME).
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Dr Alastair Lamb
10th February 2025
Our lab focusses on Spatial Prostate Assessment and the Circulating Environment (aka the SPACE Group). We use cutting edge spatial molecular techniques to unpack clonal dynamics in the development of localised prostate cancer. Alongside this we seek to identify scalable “windows” into clonal lethality using machine learning approaches applied to histology and MRI images as well as ‘liquid biopsy’ of circulating tumour cells (CTCs). Our aim is to transform decision-making in clinical management of prostate cancer so that the right men get the right treatment at the right time.
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Dr Tamsin Wilcock
8th August 2024
My research focuses on developing novel methodology for in-cell monitoring of direct downstream kinase phosphorylation and phospho-isoform substrate specificity. This work will contribute towards enhancing our understanding of cell cycle protein signalling and elucidating the role of the activation loop in substrate switching.
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Dr James Scarth
8th August 2024
My research employs 3D tissue models of oncogenic HPV infection to study the contribution of oncogene-induced replication stress (Oi-RS) and genomic instability to cancer initiation.
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Dr Sandra M. Martin-Guerrero
7th August 2024
My work is focused on exploiting cell cycle vulnerabilities in tumour cells, particularly the role of MASTL or Greatwall kinase in cell cycle control. My research will explore the role of MASTL in AML and whether it could be a new therapeutic target in this disease.
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Professor Francesca Ciccarelli
27th October 2023
Our group investigates cancer evolution, with a focus on understanding how genetic changes influence disease progression, response to therapy and development of resistance. We particularly concentrate on gastrointestinal cancers such as colorectal, stomach and oesophageal cancer.
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