Staff Centre: Centre for Haemato-Oncology
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Dr Mike Williams
8th August 2024
My research focusses on understanding cancer-specific metabolism in acute myeloid leukaemia and targeting this metabolism to overcome therapeutic resistance. I also explore the role of diet and obesity in leukaemogenesis and response to therapy.
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Dr Megha Meena
7th August 2024
We use novel mass cytometry technology following allogeneic haematopoietic stem-cell transplantation in patients, to define the global landscape of immune-cell populations preceding development of acute graft-versus-host disease (aGvHD) and to identify a dominant immunoregulatory role for subsets of CD56hi NK cells in limiting alloreative T-cell expansion and aGvHD.
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Dr Amanda Jimenez-Pompa
7th August 2024
I am interested in unveiling and modelling the mechanisms that drive clonal haematopoiesis and exploring niche-based therapies to prevent it, as clonal haematopoiesis has been recently linked to an increase in the development of leukaemia and cardiovascular conditions.
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Dr Lou Salome Herman
7th August 2024
My current research focuses on investigating B and T cell population differences in chronic lymphocytic leukaemia (CLL) mouse models before and after Bruton Tyrosine Kinase (BTK) inhibitor treatments.
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Dr Arantxa Carrasco Leon
7th August 2024
My research project aims to identify germline mutations in acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) and to understand their contribution in the development of these haematological diseases, using in vitro and ex vivo models. This study will lead to a step forward in the diagnosis and treatment of this group of life-threatening diseases.
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Dr James Boncan
26th January 2023
My research investigates the functional relevance of RNA-binding proteins (RBPS) in normal haematopoiesis and acute myeloid leukaemia (AML) pathogenesis.
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