My research project aims to identify germline mutations in acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) and to understand their contribution in the development of these haematological diseases, using in vitro and ex vivo models. This study will lead to a step forward in the diagnosis and treatment of this group of life-threatening diseases.
My research aims to understand the mechanisms through which long noncoding RNAs can control genome stability in cancer.
My lab aims to understand the basic mechanisms controlling DNA replication in mammalian cells and how disruption of this process leads to genomic instability and cancer.
My research activity aims to characterise lncRNAs involved in the maintenance of genomic stability and to understand how their dysregulation can lead to cancer development.
My group combines mathematics, computer simulations and genomic information to study evolutionary processes. We aim to understand how a tumour’s evolutionary history is reflected in its genome, how evolution can be quantified in individual tumours and how this information predicts future evolution.
My research is focused on describing the mechanisms underlying Lamin B1 nuclear disassembly in B-cell normal development and how a dis-regulated Lamin B1 removal pathway could lead to several haematological malignancies within the germinal centre in secondary lymph organs.