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Dr Lauryn Buckley-Benbow
My research investigates the mechanisms of sensitisation to PARP and ATR inhibitors and how dysfunction of normal DNA replication leads to genome instability and cancer.
Dr Kirsty Brooksbank
My research is focussed on trying to understand the connection between DNA damage repair deficiency and response to immune checkpoint inhibitors (ICIs). We have a particular focus on investigating the variable response rates to ICIs observed in DNA mismatch repair deficient cancers.
Dr Alessandro Agnarelli
My research focuses on investigating the roles of DNA Polymerase Epsilon (Pol ε) in nucleosome assembly. Using a range of biochemical and biophysical techniques (including LC-MS, Cryo-EM), my aim is to elucidate the structural analysis of the interaction between DNA Pol ε and parental histones H3-H4 at replication fork.
Dr Özgen Deniz
Senior Lecturer
Our research aims to understand the epigenetic regulation of transposable elements and how their dysregulation contributes to the generation and development of cancer. In particular, we investigate their roles as gene regulators and triggers of anti-tumour immunity in blood cancers.
Dr Sam Wallis
My research uses microscopy to examine how microtubule post-translational modifications affect DNA damage repair and how this could be exploited to enhance chemotherapy.
Dr Alice Coomer
My research aims to understand the mechanisms through which long noncoding RNAs can control genome stability in cancer.