I study the biology of tumour invasion with a particular focus on the roles of the adhesion molecules expressed on the cell surface that mediate this process. Our group concentrates on the study of integrins that are the principal family of adhesion molecules that mediate the interaction between cells and the extracellular matrix.
The focus of our lab is to study how inflammation, via modulating cellular metabolism, affects different aspects of cancer biology. In particular, we are interested in understating how obesity-associated inflammation rewires cellular metabolism, increasing the risk of breast cancer in obese women.
My group’s work focuses on the role of the tumour suppressor protein LIMD1 and its family members Ajuba and WTIP and how their deregulation in normal tissue contributes to the development of lung, renal and breast cancer.
