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Discovery reveals new understanding of cancer-driving proteins in rare brain tumours and beyond

7th November 2025

Scientists have discovered that a single letter change in a gene called PRKCA drives a rare and hard-to-treat brain cancer, chordoid glioma, through an entirely unexpected mechanism. The findings could open up new ways to design targeted treatments for this difficult-to-treat disease, and possibly for other cancers involving the same gene.

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Scientists explore new way to bring CAR-T cell therapy to pancreatic cancer

22nd May 2025

A new strategy to help powerful cancer-targeting immune cells, known as CAR-T cells, infiltrate pancreatic tumours has been developed by researchers at Barts Cancer Institute, Queen Mary University of London. The unique three-pronged approach could pave the way for making CAR-T cell therapy—a treatment that has transformed care for certain blood cancers—effective against pancreatic cancer, a disease that remains very difficult to treat.

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Video: mini-tumours shed light on how pancreatic cancer spreads

19th December 2023

We spoke to Professor Richard Grose about his lab’s latest study, which uses mini-tumours to understand how pancreatic cancer coerces normal cells to help it spread to other tissues. The new paper has been featured on the cover of the latest issue of the Journal of Pathology.

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Dr Mirjana Efremova awarded £1m Cancer Research UK grant to decode bowel cancer’s plastic nature

14th December 2023

Congratulations to Dr Mirjana Efremova who has been awarded a £1m grant to use cutting-edge computational tools to study how bowel cancer adapts.

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World Pancreatic Cancer Day: research reveals molecules that alter the disease’s spread

16th November 2023

‘Star-shaped’ cells in the pancreas emit molecules that alter the tumour’s aggressiveness

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New study suggests promising approach for treating pancreatic cancer

18th October 2023

Researchers have pinpointed the cells that drive the spread of pancreatic cancer and revealed a weakness in these cells that could be targeted using existing cancer drugs.

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