Dr Kevin Rouault-Pierre

Dr Kevin Rouault-Pierre

BSc, MSc, PhD
Centre: Centre for Haemato-Oncology
Lecturer
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My main research interests are in haematopoietic stem cells (HSCs) and leukemic initiating cells. I seek to understand how intrinsic and extrinsic signals are integrated by normal and malignant stem cells.

Research Details

Myelodysplastic Syndromes (MDS) and Acute myeloid leukaemia (AML) are both clonal diseases that harbour MDS stem cells (MDS-SC) and pre-leukemic cells, respectively. Various studies have demonstrated that acquired mutations in haematopoietic cells' genes can lead to clonal fitness and eventually to propagation of the disease. Understanding the switch between clonal haematopoiesis and clonal disease is one of the major challenges of the scientific community, which highlights the need to unravel how epigenetic/spliceosome stresses are integrated by stem cells and dictate their clonal fate.

Profile

I have been developing my expertise on haematopoietic stem cells and multiple cancer fields throughout my career and have beneficiated in particular of the Francis Crick Institute’s world-class environment, with one of the world leaders in the haematology and stem cell field, Dr Dominique Bonnet. The work conducted in Dr Bonnet’s group in collaboration with Prof. Mufti from King’s College Hospital has significantly contributed to providing me with the tools and knowledge for the project I am developing.


In September 2017 I was awarded the Kay Kendall Leukaemia intermediate fellowship and joined the Barts Cancer Institute at the Centre for Haemato-Oncology led by Prof John Gribben.

Funding

Kay Kendall Leukaemia Fund intermediate fellowship - £287,000

Key Publications

Preclinical modeling of myelodysplastic syndromes. Rouault-Pierre K*, Mian SA*, Goulard M, Abarrategi A, Di Tullio A, Smith AE, Mohamedali A, Best S, Nloga AM, Kulasekararaj G, Lionel A, Chomienne C, Fenaux P, Dosquet C*, Mufti GJ* and Bonnet D*. Leukemia, 2017 PMID:28663577

Myelodysplastic synrome can propagate from the multipotent progenitor compartment. Rouault-Pierre K*, Smith AE*, Mian SA, Pizzitola I, Kulasekararaj AG, Mufi GJ, Bonnet D. Haematologica 102(1):e7-e10 2016 PMID:PMC5210239

SF3B1 mutant MDS initiating-cells may arise from the haematopoietic stem cell compartment. Mian AS*, Rouault-Pierre K*, Smith AE, Seidl T, Mohamedali AM, Kulasekararaj AG, Bonnet D and Mufti GJ. Nature Communications, 6:10004 2015 PMID:26643973

HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress. Rouault-Pierre K*, Lopez-Onieva L*, Foster K, Anjos-Afonso F, Lamrissi-Garcial, Serrano-Sanchez M, Mitter R, Ivanovic Z, de Verneuil H, Gribben J, Taussig D, Rezvani HR, Mazurier F, Bonnet D. Cell Stem Cell, 13(5):549-63 2013 PMID:24095676

 

My main research interests are in haematopoietic stem cells (HSCs) and leukemic initiating cells. I seek to understand how intrinsic and extrinsic signals are integrated by normal and malignant stem cells.

External Activities

Member of the European Haematology Association

Member of the Société Française d'Hématologie

News

A post-doctoral position will be available in the coming months. If you are high-motivated, curious with a background in molecular/cellular biology and a high interest in haematology and stem cells, you are encouraged to contact me.

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