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ARIA-funded epiPRIME team
Scientists awarded £5.7m to harness epigenetics in next-generation anti-viral therapies

25th June 2026

Researchers have discovered a way in which the environment surrounding triple-negative breast cancer cells helps suppress our immune system, making this cancer harder to treat. The findings open the door to a potential new treatment strategy that could make triple-negative breast cancers more vulnerable to the immune system and help more people to benefit from immunotherapy in future.

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Germinal centre-like structures in the salivary glands of a patient with Sjögren’s syndrome. This microscopy image shows the relationship between molecules involved in the cell’s recycling process (autophagy; shown in red) and Lamin B1 (in green), a protein found at the edge of the cell nucleus. Areas with increased autophagy activity correspond to regions with lower amounts of Lamin B1, suggesting this recycling process helps control Lamin B1 levels in immune cells during autoimmune disease.
Cells’ recycling system plays a surprising role in shaping immune cells DNA

2nd July 2025

Researchers have discovered a new mechanism by which B cells – antibody-producing immune cells – use a cellular recycling process called autophagy to control changes to their DNA essential for antibody improvement. The findings could have future implications for the development of certain blood cancers and autoimmune diseases.

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Illustration of a blue cancer cell
Smarter chemotherapy approach could delay drug resistance in ovarian cancer

30th April 2025

Adaptive chemotherapy can prolong survival in lab models of ovarian cancer, according to new results. The findings could pave the way for a more effective and gentler approach to treating ovarian cancer that uses existing drugs in a more intelligent way.

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Staining from a human melanoma patient. Melanoma cells are highlighted in green. Individual cells are present in the invasion area, exhibiting an amoeboid/rounded shape near blood vessels.
Scientists discover the ‘roadmap’ that aggressive cancer uses to spread around the body and identify ways to block its escape

14th February 2025

Scientists have discovered a new way to predict which tumours will become aggressive before they metastasise and spread around the body. The findings could help doctors spot which tumours are likely to be aggressive and cause metastatic cancer. They also open new avenues for treating cancer before it spreads.

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Illustration of a cell
Protein level predicts immunotherapy response in bowel cancer

16th January 2025

Researchers have shown that the amount of a protein called CD74 can indicate which people with bowel cancer may respond best to immunotherapy.

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Discovery of lingering DNA damage could change our understanding of cancer development

15th January 2025

Dr Michael Spencer Chapman and team have uncovered forms of DNA damage in healthy cells that can persist unrepaired for years

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