Tag: Immunology

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Germinal centre-like structures in the salivary glands of a patient with Sjögren’s syndrome. This microscopy image shows the relationship between molecules involved in the cell’s recycling process (autophagy; shown in red) and Lamin B1 (in green), a protein found at the edge of the cell nucleus. Areas with increased autophagy activity correspond to regions with lower amounts of Lamin B1, suggesting this recycling process helps control Lamin B1 levels in immune cells during autoimmune disease.
Cells’ recycling system plays a surprising role in shaping immune cells DNA

2nd July 2025

Researchers have discovered a new mechanism by which B cells – antibody-producing immune cells – use a cellular recycling process called autophagy to control changes to their DNA essential for antibody improvement. The findings could have future implications for the development of certain blood cancers and autoimmune diseases.

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Illustration of a cell
Protein level predicts immunotherapy response in bowel cancer

16th January 2025

Researchers have shown that the amount of a protein called CD74 can indicate which people with bowel cancer may respond best to immunotherapy.

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Immunofluorescence microscopy image of cells in pancreatic ductal adenocarcinoma.
How non-cancerous cells in pancreatic cancer may weaken the immune system’s response

12th December 2024

New research sheds light on how certain non-cancerous cells in pancreatic cancer can affect the body’s natural immune defences and could have a significant impact on patients’ survival.

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Video: Engineering a Tumour on a Chip

29th August 2024

Meet Dr Joash Joy, a postdoctoral researcher working on engineering artificial tumours to explore how cancer therapies can be made more effective.

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Dr Luigi Ombrato awarded Cancer Research UK grant to understand how the seeds of secondary tumours grow

21st March 2024

Congratulations to Dr Luigi Ombrato who has been awarded a £700k grant to investigate the earliest stages of cancer spread.

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Illuminating the city of cells inside cancer
Video: Illuminating the city of cells inside cancer

6th July 2023

A new technique produces stunning, nebula-like images of tumours that provide crucial insights into cancer, how it behaves and how our immune cells attempt to fight it.

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